Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | JUN | P05412 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177363 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KMT2ALMNAMAPTGAA | |
| SCHEMBL27827809 | 0.75 | ALDH1A1 (0.41) | ALDH1A1KMT2AMAPTGAANPSR1 | |
| SCHEMBL1661666 | 0.71 | ALDH1A1 (0.34) | ALDH1A1KMT2ALMNAMAPTGAA | |
| SCHEMBL31582761 | 0.71 | ALDH1A1 (0.34) | ALDH1A1KMT2AMAPTPOLB | |
| SCHEMBL17653940 | 0.68 | ALDH1A1 (0.50) | ALDH1A1KMT2ALMNAMAPTGAA | |
| SCHEMBL15240341 | 0.68 | LMNA (0.49) | KMT2ALMNAGAAKDM4EPOLB | |
| SCHEMBL14840925 | 0.68 | ALDH1A1 (0.41) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1515625 | 0.68 | GABRA5 (0.40) | KMT2A | |
| SCHEMBL29593341 | 0.68 | ALDH1A1 (0.41) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8082304 | 0.67 | SLC6A4 (0.59) | ALDH1A1KMT2ALMNAMAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118076606-A | Imidazopyridazine IL-17 inhibitor compounds | 詹森药业有限公司 | 2024-05-24 | — | — | CN | disclosed |
| EP-4143195-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | Janssen Pharmaceutica NV (BE) | 2023-03-08 | — | — | EP | disclosed |
| EP-3233839-A1 | HETEROCYCLYL LINKED IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KBETA INHIBITORS | Janssen Pharmaceutica NV (BE) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097359-A1 | HETEROCYCLYL LINKED IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-23 | — | — | WO | disclosed |