Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | CCR9 | P51686 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31582761 | 0.77 | ALDH1A1 (0.34) | ALDH1A1KMT2AMAPTCCR9POLB | |
| SCHEMBL27827809 | 0.73 | ALDH1A1 (0.41) | ALDH1A1KMT2AMAPTPOLBMEN1 | |
| SCHEMBL17849008 | 0.71 | ALDH1A1 (0.40) | ALDH1A1KMT2ALMNAMAPTKDM4E | |
| SCHEMBL29223296 | 0.71 | LMNA (0.40) | ALDH1A1KMT2ALMNAMAPTMAPKAPK2 | |
| SCHEMBL29686979 | 0.69 | AKR1B1 (0.44) | ALDH1A1KMT2ALMNAMAPTKDM4E | |
| SCHEMBL19975190 | 0.69 | AKR1B1 (0.44) | ALDH1A1KMT2ALMNAMAPTKDM4E | |
| SCHEMBL13180802 | 0.69 | CYP1A2 (0.40) | ALDH1A1LMNAMAPKAPK2L3MBTL1KDM4E | |
| SCHEMBL17261450 | 0.69 | FDPS (0.51) | — | |
| SCHEMBL29636350 | 0.69 | LMNA (0.31) | LMNA | |
| SCHEMBL2656228 | 0.68 | ALDH1A1 (0.39) | ALDH1A1KMT2ALMNAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |