Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.31 |
| ▸ | TYK2 | P29597 | 2/20 | 0.31 |
| ▸ | TYMS | P04818 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17849244 | 0.81 | TYK2 (0.40) | JAK2JAK1MAPK14LRRK2TYK2 | |
| SCHEMBL16623511 | 0.78 | TYK2 (0.38) | PARP1JAK2TYK2 | |
| SCHEMBL16726648 | 0.77 | KDR (0.33) | PARP1 | |
| SCHEMBL17849218 | 0.77 | HDAC6 (0.40) | PARP1MAPK14 | |
| SCHEMBL16623558 | 0.76 | PARP1 (0.34) | PARP1 | |
| SCHEMBL17849239 | 0.76 | HDAC1 (0.46) | PARP1JAK2JAK1 | |
| SCHEMBL17849245 | 0.76 | NPC1 (0.41) | JAK2LRRK2TYK2 | |
| SCHEMBL16623502 | 0.74 | LRRK2 (0.32) | MCL1LRRK2 | |
| SCHEMBL16726656 | 0.73 | PTGS2 (0.33) | PARP1TYK2 | |
| SCHEMBL16623503 | 0.73 | EGFR (0.35) | PARP1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |