Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 3/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623354 | 0.91 | POLB (0.57) | POLBTDP1HRH3HSP90AA1MEN1 | |
| SCHEMBL9971990 | 0.84 | HSP90AA1 (0.54) | POLBTDP1HRH3HSP90AA1KMT2A | |
| SCHEMBL9971921 | 0.82 | P2RX7 (0.49) | POLBTDP1HRH3HSP90AA1MEN1 | |
| SCHEMBL31464419 | 0.82 | POLB (0.50) | POLBTDP1HRH3HSP90AA1MEN1 | |
| SCHEMBL12093445 | 0.80 | PKM (0.67) | POLBTDP1HRH3HSP90AA1MEN1 | |
| SCHEMBL21170645 | 0.80 | HRH3 (0.54) | POLBTDP1HRH3HSP90AA1MEN1 | |
| SCHEMBL9971991 | 0.79 | HSP90AA1 (0.51) | POLBTDP1HRH3HSP90AA1MEN1 | |
| SCHEMBL17850234 | 0.78 | POLB (0.59) | POLBTDP1HSP90AA1MEN1KMT2A | |
| SCHEMBL4751256 | 0.77 | HSP90AA1 (0.55) | POLBTDP1HRH3HSP90AA1KMT2A | |
| SCHEMBL21279501 | 0.77 | POLB (0.49) | POLBTDP1HRH3HSP90AA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424869-B1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LTD (GB) | 2016-06-22 | — | — | EP | disclosed |