Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14117676 | 0.84 | HRH3 (0.54) | HRH3POLBTDP1HSP90AA1L3MBTL1 | |
| SCHEMBL4751256 | 0.84 | HSP90AA1 (0.55) | HRH3POLBTDP1HSP90AA1CA12 | |
| SCHEMBL12093445 | 0.84 | PKM (0.67) | HRH3POLBTDP1HSP90AA1LMNA | |
| SCHEMBL10883109 | 0.84 | SIGMAR1 (0.62) | HRH3POLBTDP1HSP90AA1L3MBTL1 | |
| SCHEMBL24018903 | 0.82 | KMT2A (0.46) | HRH3POLBTDP1L3MBTL1MEN1 | |
| SCHEMBL23967996 | 0.82 | MEN1 (0.43) | HRH3LMNAMEN1RAB9AKMT2A | |
| SCHEMBL623354 | 0.81 | POLB (0.57) | HRH3POLBTDP1HSP90AA1HSD11B1 | |
| SCHEMBL12090013 | 0.81 | ALDH1A1 (0.57) | HRH3POLBTDP1HSP90AA1L3MBTL1 | |
| SCHEMBL9971990 | 0.80 | HSP90AA1 (0.54) | HRH3POLBTDP1HSP90AA1PARP1 | |
| SCHEMBL9971991 | 0.80 | HSP90AA1 (0.51) | HRH3POLBTDP1HSP90AA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787458-B2 | Chiral synthesis of N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-A]pyrazines | OGEDA SA (BE) | 2020-09-29 | — | — | US | disclosed |
| US-20190218225-A1 | NOVEL CHIRAL SYNTHESIS OF N-ACYL-(3-SUBSTITUTED)-(8-SUBSTITUTED)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES | OGEDA SA. (BE) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787458-B2 | Chiral synthesis of N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-A]pyrazines | NAA15, AADAC, NAT1 | HRH3 3281/4885POLB 2121/4885TDP1 3774/4885 |
| US-20190218225-A1 | NOVEL CHIRAL SYNTHESIS OF N-ACYL-(3-SUBSTITUTED)-(8-SUBSTITUTED)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES | NAA15, AADAC, API5 | HRH3 3340/4885POLB 2813/4885TDP1 3819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.