Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PHGDH | O43175 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170645 | 0.84 | HRH3 (0.54) | HSP90AA1HRH3POLBTDP1SMN1; SMN2 | |
| SCHEMBL14117676 | 0.84 | HRH3 (0.54) | HSP90AA1HRH3POLBTDP1RAB9A | |
| SCHEMBL12093445 | 0.84 | PKM (0.67) | HSP90AA1HRH3POLBTDP1GAA | |
| SCHEMBL10883109 | 0.84 | SIGMAR1 (0.62) | HSP90AA1HRH3POLBTDP1RAB9A | |
| SCHEMBL12090013 | 0.84 | ALDH1A1 (0.57) | HSP90AA1HRH3POLBTDP1SMN1; SMN2 | |
| SCHEMBL106697 | 0.84 | HPGD (0.59) | HSP90AA1HRH3POLBTDP1SMN1; SMN2 | |
| SCHEMBL9971990 | 0.83 | HSP90AA1 (0.54) | HSP90AA1HRH3POLBTDP1SMN1; SMN2 | |
| SCHEMBL9971981 | 0.82 | PKM (0.54) | HSP90AA1POLBTDP1SMN1; SMN2GAA | |
| SCHEMBL105677 | 0.80 | HSP90AA1 (0.57) | HSP90AA1POLBTDP1SMN1; SMN2GAA | |
| SCHEMBL10008491 | 0.80 | HPGD (0.56) | HRH3POLBTDP1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008136754-A1 | NOVEL BENZYL - 2 -OXO-PIPERAZINYL/ 7-OXO/5-OXA- [1,4] DIAZEPANYL/ 2 -OXO- TETRAHYDROPYRIMIDINYL DERIVATIVES | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |