Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 5/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | PRKACA | P17612 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194695 | 0.80 | FGFR1 (0.45) | CDC7MAP4K4ROCK2PIM1CDK2 | |
| SCHEMBL9952518 | 0.79 | CDC7 (0.44) | CDC7MAP4K4ROCK2PIM1CDK2 | |
| SCHEMBL10194692 | 0.78 | SIGMAR1 (0.44) | CDC7FLT1LRRK2FGFR1SIGMAR1 | |
| SCHEMBL10194875 | 0.78 | FGFR1 (0.42) | CDC7MAP4K4ROCK2PIM1CDK2 | |
| SCHEMBL9952065 | 0.76 | CDC7 (0.46) | CDC7MAP4K4ROCK2PIM1CDK2 | |
| SCHEMBL10194729 | 0.76 | LRRK2 (0.45) | CDC7MAP4K4ROCK2PIM1CDK2 | |
| SCHEMBL9952277 | 0.74 | NPC1 (0.44) | CDC7MAP4K4ROCK2PIM1CDK2 | |
| SCHEMBL17850455 | 0.74 | GRM4 (0.46) | CDC7MAP4K4ROCK2PIM1CDK2 | |
| SCHEMBL9951810 | 0.72 | FKBP1A (0.47) | CDC7FLT1LRRK2FGFR1ITK | |
| SCHEMBL9953146 | 0.72 | POLB (0.42) | CDC7MAP4K4ROCK2PIM1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |