SCHEMBL17850786

SCHEMBL17850786

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nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.46
KDM4E B2RXH2 1/20 0.46
ALOX15 P16050 1/20 0.39
HSD17B10 Q99714 1/20 0.39
CPB1 P15086 1/20 0.35
CYP2C19 P33261 1/20 0.34
LDHA P00338 1/20 0.33
SRR Q9GZT4 1/20 0.33
GRIK1 P39086 1/20 0.32
GRIK2 Q13002 1/20 0.32
ALDH1A1 P00352 1/20 0.30
MAPK1 P28482 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5332727 0.84 TSHR (0.52) TSHRKDM4EALOX15HSD17B10CPB1
SCHEMBL464973 0.78 ALDH1A1 (0.36) TSHRGRIK1GRIK2ALDH1A1
SCHEMBL22842694 0.78 GRIK1 (0.35) TSHRGRIK1GRIK2TDP1
SCHEMBL1331074 0.76 TSHR (0.54) TSHRKDM4EALOX15HSD17B10CPB1
SCHEMBL4414112 0.76 GRIK1 (0.53) TSHRKDM4EALOX15HSD17B10CPB1
SCHEMBL4414116 0.76 GRIK1 (0.53) TSHRKDM4EALOX15HSD17B10CPB1
SCHEMBL23509654 0.74 ALOX15 (0.34) TSHRALOX15HSD17B10LDHASRR
SCHEMBL1160283 0.74 CAMK2A (0.38)
SCHEMBL16527300 0.74 GRIK1 (0.43) TSHRGRIK1GRIK2ALDH1A1TDP1
SCHEMBL16610060 0.74 GRIK1 (0.33) GRIK1GRIK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2636665-B1 METHOD FOR PRODUCING ESTER UNIV NAGOYA NAT UNIV CORP (JP) 2016-06-22 EP disclosed