Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723332 | 0.90 | HDAC8 (0.70) | HDAC8PDK2HDAC6CRBNKMO | |
| Trifluoroacetic Acid SCHEMBL1786802 | 0.85 | CES1 (0.52) | HDAC8PDK2HDAC6HDAC1HDAC2 | |
| SCHEMBL13702375 | 0.85 | HDAC8 (0.68) | HDAC8PDK2HDAC6CRBNKMO | |
| SCHEMBL9056834 | 0.82 | CRBN (0.61) | HDAC8PDK2HDAC6CRBNHDAC2 | |
| Trifluoroacetic Acid SCHEMBL6300559 | 0.82 | KMO (0.75) | HDAC8PDK2HDAC6KMOHDAC1 | |
| Trifluoroacetic Acid SCHEMBL27749215 | 0.81 | PDK2 (0.57) | HDAC8PDK2KMOMAPT | |
| SCHEMBL12168604 | 0.81 | EPHX2 (0.60) | HDAC8HDAC6CRBNKMOCDK8 | |
| Trifluoroacetic Acid SCHEMBL7759604 | 0.79 | DHODH (0.58) | HDAC8PDK2KMOCYP3A4POLB | |
| SCHEMBL2832472 | 0.79 | HDAC8 (0.64) | HDAC8KMOGRM5KAT6ANR1H4 | |
| SCHEMBL14210412 | 0.79 | CRBN (0.58) | HDAC8PDK2HDAC6CRBNCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124559-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124559-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | OPRL1, OPRM1, OPRK1 | HDAC8 2033/4885PDK2 4021/4885HDAC6 1298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.