Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16921861 | 0.89 | NPC1 (0.35) | NPC1TP53RAB9ASMN1; SMN2TSHR | |
| SCHEMBL16921979 | 0.86 | HRH3 (0.45) | NPC1TP53RAB9ASMN1; SMN2TSHR | |
| SCHEMBL16922049 | 0.81 | ALDH1A1 (0.34) | ALDH1A1KDM4EHRH3 | |
| SCHEMBL16921799 | 0.81 | ALDH1A1 (0.34) | NPC1TP53RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16922031 | 0.77 | CTH (0.36) | — | |
| SCHEMBL16921832 | 0.77 | CTH (0.36) | NPC1TP53RAB9ASMN1; SMN2TSHR | |
| SCHEMBL15597850 | 0.74 | CTH (0.42) | NPC1TP53RAB9ASMN1; SMN2TSHR | |
| SCHEMBL16921943 | 0.73 | ALPL (0.33) | TP53TSHRALDH1A1CYP1A2GAA | |
| SCHEMBL27047817 | 0.71 | NPC1 (0.35) | NPC1TP53RAB9ASMN1; SMN2TSHR | |
| SCHEMBL8315382 | 0.71 | ALOX15 (0.37) | NPC1TP53RAB9ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016099311-A1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS | OncoArendi Therapeutics Sp. z o.o. (PL) | 2016-06-23 | — | — | WO | disclosed |