Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHIT1 | Q13231 | 5/20 | 0.45 |
| ▸ | CHIA | Q9BZP6 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CCR3 | P51677 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17838822 | 0.88 | CHIT1 (0.49) | CHIT1CHIAKCNH2MEN1KMT2A | |
| SCHEMBL17853351 | 0.80 | CCR3 (0.48) | CHIT1CHIAKCNH2NR1D1MEN1 | |
| SCHEMBL17838891 | 0.78 | CHIT1 (0.58) | CHIT1CHIAKCNH2 | |
| SCHEMBL17838815 | 0.77 | MEN1 (0.53) | CHIT1CHIAKCNH2NR1D1MEN1 | |
| SCHEMBL17847358 | 0.76 | CHIT1 (0.51) | CHIT1CHIAKCNH2 | |
| SCHEMBL16097143 | 0.76 | KMT2A (0.62) | MEN1KMT2AGPR119 | |
| SCHEMBL17853481 | 0.75 | NR1D1 (0.53) | CHIT1CHIAKCNH2NR1D1MEN1 | |
| SCHEMBL14635700 | 0.74 | HTT (0.47) | MEN1KMT2ASMN1; SMN2TP53THRB | |
| SCHEMBL17838866 | 0.73 | MEN1 (0.49) | CHIT1CHIAKCNH2NR1D1MEN1 | |
| SCHEMBL17838855 | 0.72 | STS (0.48) | NR1D1MEN1KMT2ASMN1; SMN2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233832-B1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS | ONCOARENDI THERAPEUTICS SA (PL) | 2019-11-20 | — | — | EP | disclosed |
| US-20160368894-A1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS | OncoArendi Therapeutics Sp. z o.o. (PL) | 2016-12-22 | — | — | US | disclosed |
| US-20160368894-A1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS | OncoArendi Therapeutics Sp. z o.o. (PL) | 2016-12-22 | — | — | US | disclosed |
| US-9440953-B2 | Substituted amino triazoles useful as acidic mammalian chitinase inhibitors | OncoArendi Therapeutics Sp. z o.o. (PL) | 2016-09-13 | — | — | US | disclosed |
| US-9440953-B2 | Substituted amino triazoles useful as acidic mammalian chitinase inhibitors | OncoArendi Therapeutics Sp. z o.o. (PL) | 2016-09-13 | — | — | US | disclosed |
| US-20160176843-A1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS | OncoArendi Therapeutics Sp. z o.o. (PL) | 2016-06-23 | — | — | US | disclosed |
| US-20160176843-A1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS | OncoArendi Therapeutics Sp. z o.o. (PL) | 2016-06-23 | — | — | US | disclosed |
| WO-2016099311-A1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS | OncoArendi Therapeutics Sp. z o.o. (PL) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176843-A1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS | CHIA, CHIT1, CMA1 | CHIT1 2/4885CHIA 1/4885KCNH2 4758/4885 |
| US-20160368894-A1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS | CHIA, CHIT1, CMA1 | CHIT1 2/4885CHIA 1/4885KCNH2 4758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.