Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25993959 | 0.81 | USP30 (0.36) | HTTMAPTHPGDSTP53DDB1 | |
| SCHEMBL12354143 | 0.81 | GPR119 (0.55) | NAMPTMAPTKDM4ETHRBHPGDS | |
| SCHEMBL29386809 | 0.81 | GPR119 (0.55) | NAMPTMAPTKDM4ETHRBHPGDS | |
| SCHEMBL25993972 | 0.78 | UCHL1 (0.41) | — | |
| SCHEMBL4457404 | 0.78 | NAMPT (0.48) | HTTNAMPTMAPTKDM4ETHRB | |
| SCHEMBL6530981 | 0.77 | CHEK2 (0.58) | HTTGPR119 | |
| SCHEMBL14636120 | 0.77 | NAMPT (0.51) | NAMPT | |
| SCHEMBL1558412 | 0.77 | NAMPT (0.54) | NAMPTMAPTKDM4ETHRBGPR119 | |
| SCHEMBL30563607 | 0.77 | GPR119 (0.65) | NAMPTMAPTKDM4ETHRBTP53 | |
| SCHEMBL30673157 | 0.77 | NAMPT (0.54) | NAMPTMAPTKDM4ETHRBGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013010453-A1 | CHEMOKING RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2013-01-24 | — | — | WO | disclosed |