SCHEMBL178550

SCHEMBL178550

COc1cccc(F)c1O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.64
KDM4E B2RXH2 3/20 0.64
TP53 P04637 2/20 0.64
MAPK1 P28482 2/20 0.64
HPGD P15428 2/20 0.64
CYP3A4 P08684 2/20 0.64
ALOX15 P16050 2/20 0.64
ALDH1A1 P00352 1/20 0.64
LMNA P02545 1/20 0.64
ALOX12 P18054 1/20 0.64
HSD17B10 Q99714 1/20 0.64
TLR2 O60603 1/20 0.52
ERN1 O75460 1/20 0.52
TLR1 Q15399 1/20 0.52
TLR6 Q9Y2C9 1/20 0.52
TDP1 Q9NUW8 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
TSHR P16473 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30416971 1.00 MAPT (0.64) MAPTKDM4ETP53MAPK1HPGD
Syringol SCHEMBL156388 0.83 KDM4E (0.80) MAPTKDM4ETP53MAPK1HPGD
Syringol SCHEMBL7610366 0.80 KDM4E (0.76) MAPTKDM4ETP53MAPK1HPGD
Syringol SCHEMBL6049240 0.80 KDM4E (0.76) MAPTKDM4ETP53MAPK1HPGD
Syringol SCHEMBL8986496 0.80 KDM4E (0.76) MAPTKDM4ETP53MAPK1HPGD
SCHEMBL30417463 0.79 PTPN1 (0.41) MAPTKDM4ETP53MAPK1HPGD
SCHEMBL21262585 0.79 PTPN1 (0.41) MAPTKDM4ETP53MAPK1HPGD
SCHEMBL4015318 0.78 L3MBTL1 (0.56) MAPTKDM4EHPGDALOX15ALDH1A1
3-Methoxycatechol SCHEMBL67332 0.78 TP53 (1.00) MAPTKDM4ETP53MAPK1HPGD
3-Methoxycatechol SCHEMBL29477155 0.78 TP53 (1.00) MAPTKDM4ETP53MAPK1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 245 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7462433-B2 Undercoat layer containing charge transfer molecule, andTiO2; imaging layer; charge transfer molecule complexes with the TiO2 to form coordination bonds and the coordination bonds provide a reduction in ghosting; electrophotographic imaging members; improved image quality XEROX CORPORATION (US) 2008-12-09 US claimed
US-20070048639-A1 Undercoat layer containing charge transfer molecule, andTiO2; imaging layer; charge transfer molecule complexes with the TiO2 to form coordination bonds and the coordination bonds provide a reduction in ghosting; electrophotographic imaging members; improved image quality XEROX CORPORATION (US) 2007-03-01 US claimed
US-6989052-B1 Phase change ink printing process XEROX CORPORATION (US) 2006-01-24 US claimed
US-20060004123-A1 PHASE CHANGE INK PRINTING PROCESS XEROX CORPORATION 2006-01-05 US claimed
US-4855476-A 3,4-DIBENZYLOXY-5-FLUOROBENZYLCYANIDE FROM 2-FLUORO-6-METHOXYP HENOL OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1989-08-08 US claimed
WO-2025245367-A1 INHIBITING CATECHOL-O-METHYLTRANSFERASE (COMT) PSY THERAPEUTICS, INC. (US) 2025-11-27 WO disclosed
CN-116234550-B Aromatic formyl substituted tricyclic compound and preparation method and application thereof 劲方医药科技(上海)股份有限公司 2024-12-27 CN disclosed
US-20240360154-A1 AROYL SUBSTITUTED TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF ZHEJIANG GENFLEET THERAPEUTICS CO., LTD. (CN) 2024-10-31 US disclosed
US-20240239774-A1 SOLUBLE ADENYLYL CYCLASE (SAC) INHIBITORS AND USES THEREOF CORNELL UNIVERSITY (US) 2024-07-18 US disclosed
CN-113637005-B KRAS inhibitors for cancer treatment 泰励生物科技(上海)有限公司 2024-05-24 CN disclosed
EP-4063358-B1 HISTONE METHYLTRANSFERASE INHIBITORS GLOBAL BLOOD THERAPEUTICS INC (US) 2024-05-22 EP disclosed
EP-4223753-A1 AROYL SUBSTITUTED TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF Genfleet Therapeutics (Shanghai) Inc. (CN) 2023-08-09 EP disclosed
EP-0658543-A1 PROCESS FOR PRODUCING $g(a)-ALKOXYIMINOPHENYLACETONITRILE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1995-06-21 EP disclosed
EP-0609885-A1 Acridinium compounds and conjugates thereof MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1994-08-10 EP disclosed
US-4855476-A 3,4-DIBENZYLOXY-5-FLUOROBENZYLCYANIDE FROM 2-FLUORO-6-METHOXYP HENOL OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1989-08-08 US disclosed
US-4737504-A INCREASE BETA-2 ADRENERGIC ACTIVITY WHILE DECREASING BETA-1; CARDIOVASCULAR AND RESPIRATORY DISORDERS OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1988-04-12 US disclosed
EP-0080012-A1 6-Chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its acid addition salts and its use as an intermediate SMITHKLINE BECKMAN CORPORATION (US) 1983-06-01 EP disclosed
EP-0007070-B1 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS HAVING DOPAMINE RECEPTOR BLOCKING ACTIVITY SMITHKLINE BECKMAN CORPORATION (US) 1983-01-19 EP disclosed
US-4265890-A ANTIPSYCHOTIC, ANTIEMETICS SMITHKLINE CORPORATION (US) 1981-05-05 US disclosed
EP-0007070-A1 2,3,4,5-Tetrahydro-1H-3-Benzazepines, process for their production and pharmaceutical compositions having dopamine receptor blocking activity SMITHKLINE BECKMAN CORPORATION (US) 1980-01-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239774-A1 SOLUBLE ADENYLYL CYCLASE (SAC) INHIBITORS AND USES THEREOF UACA, ADCYAP1R1, ADCY1 MAPT 506/4885KDM4E 4664/4885TP53 3310/4885
US-20240360154-A1 AROYL SUBSTITUTED TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF BTK, WEE1, WEE2 MAPT 4672/4885KDM4E 1724/4885TP53 1242/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.