SCHEMBL17858719

SCHEMBL17858719

Nc1ncnc2c1ncn2C1OC2COP(=O)(O)O[C@@H]3C(COP(=O)(O)O[C@H]2[C@H]1F)OC(n1cnc2c(=O)[nH]cnc21)[C@@H]3F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ STING1 Q86WV6 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21343493 1.00 STING1 (1.00) STING1
SCHEMBL22887325 1.00 STING1 (1.00) STING1
SCHEMBL24209547 0.96 STING1 (0.92) STING1
SCHEMBL21417488 0.95 STING1 (1.00) STING1
SCHEMBL24703819 0.95 STING1 (0.91) STING1
SCHEMBL24703846 0.95 STING1 (1.00) STING1
SCHEMBL23476958 0.95 STING1 (1.00) STING1
SCHEMBL24038330 0.95 STING1 (0.91) STING1
SCHEMBL17858722 0.95 STING1 (1.00) STING1
SCHEMBL18511079 0.95 STING1 (1.00) STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024006804-A2 METHODS OF ADMINISTERING A STING AGONIST LONZA SALES AG (CH) 2024-01-04 — — WO disclosed
US-20230241089-A1 STING AGONIST COMPRISING EXOSOMES FOR TREATING NEUROIMMUNOLOGICAL DISORDERS CODIAK BIOSCIENCES, INC. (US) 2023-08-03 — — US disclosed
US-11667664-B2 Cyclic dinucleotides for cytokine induction KAYLA THERAPEUTICS (FR) 2023-06-06 — — US disclosed
US-11667664-B2 Cyclic dinucleotides for cytokine induction KAYLA THERAPEUTICS (FR) 2023-06-06 — — US disclosed
US-20220395465-A1 STING AGONIST COMPRISING EXOSOMES COMBINED WITH IL-12 DISPLAYING EXOSOMES FOR TREATING A TUMOUR CODIAK BIOSCIENCES, INC. (US) 2022-12-15 — — US disclosed
US-20220168415-A1 EXTRACELLULAR VESICLES FOR VACCINE DELIVERY CODIAK BIOSCIENCES, INC. (US) 2022-06-02 — — US disclosed
US-20220017561-A1 CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION KAYLA THERAPEUTICS (FR) 2022-01-20 — — US disclosed
US-20210322327-A1 EXTRACELLULAR VESICLES COMPRISING STING-AGONIST LONZA SALES AG (CH) 2021-10-21 — — US disclosed
US-11053272-B2 Cyclic dinucleotides for cytokine induction KAYLA THERAPEUTICS (FR) 2021-07-06 — — US disclosed
US-20200255469-A1 CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION KAYLA THERAPEUTICS (FR) 2020-08-13 — — US disclosed
US-10562929-B2 Cyclic dinucleotides for cytokine induction KAYLA THERAPEUTICS (FR) 2020-02-18 — — US disclosed
US-10011630-B2 Cyclic dinucleotides for cytokine induction INVIVOGEN (FR) 2018-07-03 — — US disclosed
US-10011630-B2 Cyclic dinucleotides for cytokine induction INVIVOGEN (FR) 2018-07-03 — — US disclosed
WO-2018119274-A1 SCAFFOLDS TO TREAT SOLID TUMOR CELLS AND ESCAPE VARIANTS FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2018-06-28 — — WO disclosed
US-20170340658-A1 COMBINED USE OF A CHEMOTHERAPEUTIC AGENT AND A CYCLIC DINUCLEOTIDE FOR CANCER TREATMENT INVIVOGEN (FR) 2017-11-30 — — US disclosed
US-20170340658-A1 COMBINED USE OF A CHEMOTHERAPEUTIC AGENT AND A CYCLIC DINUCLEOTIDE FOR CANCER TREATMENT INVIVOGEN (FR) 2017-11-30 — — US disclosed
US-20160362441-A1 CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION KAYLA THERAPEUTICS (FR) 2016-12-15 — — US disclosed
US-20160362441-A1 CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION KAYLA THERAPEUTICS (FR) 2016-12-15 — — US disclosed
WO-2016096174-A1 FLUORINATED CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION INVIVOGEN (FR) 2016-06-23 — — WO disclosed
WO-2016096577-A1 COMBINED USE OF A CHEMOTHERAPEUTIC AGENT AND A CYCLIC DINUCLEOTIDE FOR CANCER TREATMENT INVIVOGEN (FR) 2016-06-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160362441-A1 CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION IL1B, IFNG, IFNAR1 STING1 4/4885
US-20170340658-A1 COMBINED USE OF A CHEMOTHERAPEUTIC AGENT AND A CYCLIC DINUCLEOTIDE FOR CANCER TREATMENT STING1, CGAS, TLR9 STING1 1/4885
US-20230241089-A1 STING AGONIST COMPRISING EXOSOMES FOR TREATING NEUROIMMUNOLOGICAL DISORDERS STING1, TLR9, TBK1 STING1 1/4885
US-11053272-B2 Cyclic dinucleotides for cytokine induction IL1B, IFNG, IFNAR1 STING1 4/4885
US-20200255469-A1 CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION IL1B, IFNG, IFNAR1 STING1 4/4885
US-10011630-B2 Cyclic dinucleotides for cytokine induction IL1B, IFNG, IFNAR1 STING1 4/4885
US-20220017561-A1 CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION IL1B, IFNG, IFNAR1 STING1 4/4885
US-20210322327-A1 EXTRACELLULAR VESICLES COMPRISING STING-AGONIST STING1, MAVS, IRF3 STING1 1/4885
US-11667664-B2 Cyclic dinucleotides for cytokine induction IL1B, IFNG, IFNAR1 STING1 4/4885
US-10562929-B2 Cyclic dinucleotides for cytokine induction IL1B, IFNG, IFNAR1 STING1 4/4885
US-20220395465-A1 STING AGONIST COMPRISING EXOSOMES COMBINED WITH IL-12 DISPLAYING EXOSOMES FOR TREATING A TUMOUR STING1, MAVS, BID STING1 1/4885
US-20220168415-A1 EXTRACELLULAR VESICLES FOR VACCINE DELIVERY HAVCR2, CD74, HMGB1 STING1 66/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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