Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 17/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 17/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14752110 | 0.83 | KCNH2 (0.44) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL1516359 | 0.83 | TOP2A (0.61) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL5908567 | 0.78 | ALDH1A1 (0.43) | TOP2ATOP2BALDH1A1 | |
| SCHEMBL29576548 | 0.78 | ALDH1A1 (0.43) | TOP2ATOP2BALDH1A1 | |
| SCHEMBL114733 | 0.77 | ADRB2 (0.60) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL29576915 | 0.74 | ALDH1A1 (0.40) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL29954963 | 0.74 | TOP2A (0.37) | TOP2ATOP2BALDH1A1 | |
| SCHEMBL22774058 | 0.74 | ALDH1A1 (0.40) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL22774763 | 0.72 | DPP4 (0.38) | TOP2ATOP2BCHRM2 | |
| SCHEMBL3403068 | 0.72 | TOP2A (0.60) | TOP2ATOP2BALDH1A1POLBCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | RECQL, BLVRB, NQO2 | TOP2A 125/4885TOP2B 31/4885ALDH1A1 1678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.