Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | FPR1 | P21462 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.30 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3512726 | 0.85 | NTRK1 (0.40) | CYP2C9TRPM8NPY5RPARP1NTRK1 | |
| SCHEMBL17848092 | 0.82 | PARP1 (0.33) | NPY5RPARP1AKR1B1PTGER4FSCN1 | |
| SCHEMBL17848247 | 0.81 | INSR (0.52) | NTRK1INSRALK | |
| SCHEMBL17859183 | 0.80 | APP (0.32) | AKR1B1 | |
| SCHEMBL17848123 | 0.78 | FFAR1 (0.36) | — | |
| SCHEMBL17848289 | 0.78 | PARP1 (0.36) | NPY5RPARP1FPR1FPR2PTGER4 | |
| SCHEMBL17848156 | 0.77 | DYRK1A (0.40) | TRPM8NPY5RMAPK1 | |
| SCHEMBL3513766 | 0.76 | VNN1 (0.35) | NPY5RMAPK1 | |
| SCHEMBL591102 | 0.75 | ABCC9 (0.35) | NPY5R | |
| SCHEMBL20102203 | 0.72 | ALK (0.45) | NTRK1INSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10336707-B2 | Heterocyclic derivatives modulating activity of certain protein kinases | EUDENDRON S.R.L. (IT) | 2019-07-02 | — | — | US | disclosed |
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | UNVERSITA' DEGLI STUDI DI MILANO (IT) | 2018-05-03 | — | — | US | disclosed |
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | UNVERSITA' DEGLI STUDI DI MILANO (IT) | 2018-05-03 | — | — | US | disclosed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | MAP4K2, MAP3K20, MAPKAPK2 | CYP2C9 4512/4885TRPM8 1270/4885NPY5R 2684/4885 |
| US-10336707-B2 | Heterocyclic derivatives modulating activity of certain protein kinases | MAP4K2, MAP3K20, MAPKAPK2 | CYP2C9 4512/4885TRPM8 1270/4885NPY5R 2684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.