Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.42 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 13/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860304 | 0.87 | PAX8 (0.49) | CASP6PLCG1PLCB3PAX8 | |
| SCHEMBL17860473 | 0.87 | CASP6 (0.51) | CASP6PLCG1PLCB3PAX8TP53 | |
| SCHEMBL17860316 | 0.85 | PLCG1 (0.56) | CASP6PLCG1PLCB3PAX8TP53 | |
| SCHEMBL17860438 | 0.79 | PAX8 (0.51) | CASP6PLCG1PLCB3PAX8 | |
| SCHEMBL17860451 | 0.79 | PAX8 (0.47) | CASP6PLCG1PLCB3PAX8 | |
| SCHEMBL17860386 | 0.78 | PAX8 (0.51) | CASP6PLCG1PLCB3PAX8TP53 | |
| SCHEMBL17860425 | 0.78 | PAX8 (0.49) | CASP6PLCG1PLCB3PAX8 | |
| SCHEMBL17860439 | 0.78 | PAX8 (0.55) | CASP6PLCG1PLCB3PAX8TP53 | |
| SCHEMBL17860423 | 0.78 | PAX8 (0.51) | CASP6PLCG1PLCB3PAX8 | |
| SCHEMBL17860513 | 0.77 | PAX8 (0.51) | CASP6PLCG1PLCB3PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |