Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860699 | 0.89 | LMNA (0.44) | LMNAMAPTMAPK1ALDH1A1TDP1 | |
| SCHEMBL4757907 | 0.88 | LMNA (0.44) | LMNAMAPTMAPK1ALDH1A1CHRM1 | |
| SCHEMBL17882020 | 0.86 | ALDH1A1 (0.44) | LMNAMAPTMAPK1ALDH1A1CHRM1 | |
| SCHEMBL17860691 | 0.85 | LMNA (0.37) | LMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL17878555 | 0.83 | LMNA (0.40) | LMNAMAPTMAPK1ALDH1A1CHRM1 | |
| SCHEMBL17860717 | 0.81 | LMNA (0.41) | LMNAMAPTMAPK1ALDH1A1CHRM1 | |
| SCHEMBL17860696 | 0.79 | MAPT (0.44) | LMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL23059638 | 0.77 | LMNA (0.40) | LMNAMAPTMAPK1ALDH1A1TDP1 | |
| SCHEMBL14991338 | 0.76 | CHRM1 (0.37) | LMNAALDH1A1CHRM1AKR1A1CHRM3 | |
| SCHEMBL17860688 | 0.76 | MAPT (0.42) | LMNAMAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100578-A2 | ANTIMICROBIAL POLYMYXINS FOR TREATMENT OF BACTERIAL INFECTIONS | MICURX PHARMACEUTICALS, INC. (US) | 2016-06-23 | — | — | WO | disclosed |