SCHEMBL17865394

SCHEMBL17865394

CC(C)CNC(=O)c1ccc(CCOc2ccc(Cl)c(-c3ccc(Cl)cc3)c2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.48
NPSR1 Q6W5P4 1/20 0.47
KDM4E B2RXH2 1/20 0.46
PSEN1 P49768 1/20 0.45
PSEN2 P49810 1/20 0.45
APH1B Q8WW43 1/20 0.45
NCSTN Q92542 1/20 0.45
APH1A Q96BI3 1/20 0.45
PSENEN Q9NZ42 1/20 0.45
NPC1 O15118 2/20 0.44
FFAR4 Q5NUL3 2/20 0.43
FFAR1 O14842 1/20 0.43
ALDH1A1 P00352 2/20 0.43
RAB9A P51151 2/20 0.43
LMNA P02545 1/20 0.43
ALOX12 P18054 1/20 0.43
KCNH2 Q12809 1/20 0.43
PPARA Q07869 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
FABP2 P12104 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17865392 0.83 HPGD (0.52) HPGDNPSR1KDM4ENPC1RAB9A
SCHEMBL17865385 0.82 HPGD (0.47) HPGDNPSR1NPC1FFAR4FFAR1
SCHEMBL17865383 0.82 CYP2C9 (0.46) HPGDNPSR1KDM4EALDH1A1SMN1; SMN2
SCHEMBL17865382 0.75 KMT2A (0.51) HPGDNPSR1KDM4ENPC1ALDH1A1
SCHEMBL17865381 0.73 HPGD (0.57) HPGDNPSR1PPARAPPARG
SCHEMBL17865388 0.73 NPSR1 (0.48) HPGDNPSR1KDM4ENPC1RAB9A
SCHEMBL17865384 0.72 ROCK2 (0.49) HPGDNPSR1LMNAGAAMEN1
SCHEMBL833266 0.71 NPC1 (0.55) NPC1FFAR1ALDH1A1RAB9APPARA
SCHEMBL4364274 0.70 MAPT (0.66) NPC1RAB9APPARASMN1; SMN2PPARG
SCHEMBL1283804 0.70 MAOB (0.72) ALDH1A1PPARAPPARGPPARDGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10299475-B2 Pesticide ISHIHARA SANGYO KAISHA, LTD. (JP) 2019-05-28 US disclosed
US-20160192651-A1 PESTICIDE ISHIHARA SANGYO KAISHA, LTD. (JP) 2016-07-07 US disclosed
EP-3037408-A1 HARMFUL ORGANISM CONTROL AGENT Ishihara Sangyo Kaisha, Ltd. (JP) 2016-06-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10299475-B2 Pesticide DDT, ACHE, KCNH1 HPGD 4335/4885NPSR1 1003/4885KDM4E 217/4885
US-20160192651-A1 PESTICIDE DDT, ACHE, KCNH1 HPGD 4335/4885NPSR1 1003/4885KDM4E 217/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.