Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.37 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.37 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.37 |
| ▸ | DTYMK | P23919 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17865749 | 1.00 | DDB1 (0.42) | DDB1CRBNADAM17MMP3HTT | |
| SCHEMBL19521198 | 0.82 | HTT (0.35) | ADAM17MMP3HTTNPC1ALDH1A1 | |
| SCHEMBL19521178 | 0.81 | ALDH1A1 (0.44) | MAPTNPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL17865738 | 0.80 | HTT (0.43) | DDB1CRBNADAM17MMP3HTT | |
| SCHEMBL20153494 | 0.80 | HTT (0.43) | DDB1CRBNADAM17MMP3HTT | |
| SCHEMBL17865748 | 0.80 | HTT (0.43) | DDB1CRBNADAM17MMP3HTT | |
| SCHEMBL17865739 | 0.80 | HTT (0.43) | DDB1CRBNADAM17MMP3HTT | |
| SCHEMBL19521241 | 0.74 | HRH4 (0.30) | — | |
| SCHEMBL19521177 | 0.73 | ADAMTS5 (0.48) | ADAMTS5 | |
| SCHEMBL20168992 | 0.72 | MMP2 (0.32) | ADAM17ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3036219-A2 | NOVEL BETA LACTAMS AS MODULATORS OF GLUTAMATE UPTAKE AND METHODS FOR USE THEREOF | Temple University Of The Commonwealth System Of Higher Education (US) | 2016-06-29 | — | — | EP | claimed |