Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.45 |
| ▸ | UBA6 | A0AVT1 | 5/20 | 0.41 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.40 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.40 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17866020 | 0.84 | UBA6 (0.43) | PRMT5WDR77UBA6 | |
| SCHEMBL17866043 | 0.83 | PRMT5 (0.42) | PRMT5WDR77UBA6NAE1CA2 | |
| SCHEMBL17866056 | 0.80 | TP53 (0.47) | PRMT5WDR77 | |
| SCHEMBL17875203 | 0.80 | PRMT5 (0.47) | PRMT5WDR77NAE1CA2GRK5 | |
| SCHEMBL17866032 | 0.80 | METTL3 (0.49) | PRMT5WDR77UBA6NAE1CA2 | |
| SCHEMBL12983619 | 0.80 | POLB (0.43) | PRMT5WDR77UBA6NAE1CA2 | |
| SCHEMBL17866063 | 0.79 | METTL3 (0.37) | PRMT5WDR77UBA6NAE1CA2 | |
| SCHEMBL17865973 | 0.79 | UBA6 (0.42) | PRMT5WDR77UBA6NAE1CA2 | |
| SCHEMBL17866045 | 0.79 | LMNA (0.43) | UBA6NAE1CA2GRK5CSNK1A1 | |
| SCHEMBL5456441 | 0.79 | KDM4E (0.52) | UBA6PIP4K2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |