Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 7/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8864632 | 0.83 | KDM4E (0.55) | MCHR1KDM4EAPAF1HSP90AA1L3MBTL1 | |
| SCHEMBL1786845 | 0.79 | NPSR1 (0.56) | KDM4EL3MBTL1ADORA1ADORA2ANPSR1 | |
| SCHEMBL1789511 | 0.75 | MAP2K4 (0.44) | KDM4ENPSR1MEN1KMT2A | |
| SCHEMBL1788575 | 0.74 | THRB (0.42) | KDM4EL3MBTL1NPSR1MEN1RAB9A | |
| SCHEMBL1788116 | 0.72 | ALDH1A1 (0.57) | KDM4EL3MBTL1TSHRNPSR1MEN1 | |
| SCHEMBL1788850 | 0.71 | NPSR1 (0.42) | KDM4EL3MBTL1BRD4NPSR1TDO2 | |
| SCHEMBL1785262 | 0.71 | ROCK1 (0.55) | KDM4ETSHRNPSR1ROCK1 | |
| SCHEMBL28681020 | 0.69 | GLA (0.42) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL1789226 | 0.67 | NPSR1 (0.64) | KDM4EL3MBTL1NPSR1TP53MEN1 | |
| SCHEMBL7892186 | 0.67 | TBXAS1 (0.46) | L3MBTL1ADORA1NPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629143-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2014-01-14 | — | — | US | disclosed |
| US-20110124642-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2011-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124642-A1 | POTASSIUM CHANNEL MODULATORS | KCNQ1, KCNQ2, KCNQ3 | MAPK13 3259/4885MAPK12 2857/4885MAPK11 2411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.