Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 2/20 | 0.42 |
| ▸ | NAE1 | Q13564 | 6/20 | 0.42 |
| ▸ | UBA3 | Q8TBC4 | 5/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ABL2 | P42684 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12986946 | 0.84 | NAE1 (0.59) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL191643 | 0.84 | NAE1 (0.59) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL17866019 | 0.79 | ADK (0.46) | SIGMAR1HTR2BADRA2COPRK1HTR6 | |
| SCHEMBL17865954 | 0.75 | ADK (0.46) | SIGMAR1HTR2BADRA2COPRK1HTR6 | |
| SCHEMBL10236879 | 0.70 | NAE1 (0.43) | SIGMAR1HTR2BADRA2COPRK1HTR6 | |
| SCHEMBL17875196 | 0.70 | NAE1 (0.51) | NAE1UBA3PRMT5METTL3TP53 | |
| SCHEMBL192044 | 0.68 | NAE1 (0.68) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL14430987 | 0.68 | NAE1 (0.49) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL192050 | 0.66 | NAE1 (0.61) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL25015554 | 0.64 | METTL3 (0.47) | ADKPRMT5METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | disclosed |