Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ABL2 | P42684 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.39 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17865954 | 0.83 | ADK (0.46) | ADKSIGMAR1ADRA2COPRK1HTR2B | |
| SCHEMBL12986946 | 0.81 | NAE1 (0.59) | — | |
| SCHEMBL191643 | 0.81 | NAE1 (0.59) | — | |
| SCHEMBL17875173 | 0.79 | SIGMAR1 (0.42) | ADKSIGMAR1ADRA2COPRK1HTR2B | |
| SCHEMBL5465354 | 0.73 | NAE1 (0.41) | ADKABL1EGFRABL2LCK | |
| SCHEMBL12983619 | 0.73 | POLB (0.43) | ADKADORA3ADORA2AADORA1 | |
| SCHEMBL10236879 | 0.73 | NAE1 (0.43) | ADKSIGMAR1ADRA2COPRK1HTR2B | |
| SCHEMBL17866056 | 0.72 | TP53 (0.47) | SIGMAR1HTR2BTP53ABL1EGFR | |
| SCHEMBL17866039 | 0.72 | UBA6 (0.44) | EGFR | |
| SCHEMBL10005047 | 0.71 | ADORA3 (0.52) | ADORA3SLC29A1ADORA2AADORA1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |