SCHEMBL17875592

SCHEMBL17875592

CCc1cccc(N2COc3ccc(C)cc3C2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VDR P11473 1/20 0.47
MAPT P10636 5/20 0.41
GAA P10253 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MGLL Q99685 1/20 0.38
RAB9A P51151 3/20 0.36
NPC1 O15118 2/20 0.36
KDM4E B2RXH2 1/20 0.36
RIPK1 Q13546 1/20 0.35
ALOX5 P09917 1/20 0.34
AGXT P21549 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
HIF1A Q16665 1/20 0.34
CCKAR P32238 1/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
KCNH2 Q12809 1/20 0.33
PRMT6 Q96LA8 1/20 0.33
ADRB1 P08588 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17875589 0.90 VDR (0.44) VDRMAPTGAASMN1; SMN2MGLL
SCHEMBL17875593 0.90 VDR (0.53) VDRMAPTGAASMN1; SMN2RAB9A
SCHEMBL25848287 0.88 VDR (0.54) VDRMAPTGAASMN1; SMN2RAB9A
SCHEMBL15307677 0.86 VDR (0.60) VDRMAPTGAASMN1; SMN2MGLL
SCHEMBL12645280 0.82 VDR (0.51) VDRMAPTGAASMN1; SMN2RAB9A
SCHEMBL17875600 0.80 MAPT (0.44) VDRMAPTGAASMN1; SMN2RAB9A
SCHEMBL21793372 0.79 KDM4E (0.43) VDRMAPTGAASMN1; SMN2RAB9A
SCHEMBL17589746 0.79 VDR (0.46) VDRMAPTGAASMN1; SMN2RIPK1
SCHEMBL15297328 0.76 VDR (0.55) VDRMAPTGAASMN1; SMN2RAB9A
SCHEMBL18960454 0.76 VDR (0.55) VDRMAPTGAASMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230133556-A1 BENZOXAZINES AND COMPOSITIONS CONTAINING THE SAME CYTEC INDUSTRIES INC 2023-05-04 US disclosed
US-20230133556-A1 BENZOXAZINES AND COMPOSITIONS CONTAINING THE SAME CYTEC INDUSTRIES INC 2023-05-04 US disclosed
US-11566106-B2 Composite materials containing benzoxazines and method for making the same CYTEC INDUSTRIES INC. (US) 2023-01-31 US disclosed
US-20200291179-A1 COMPOSITE MATERIALS CONTAINING BENZOXAZINES AND METHOD FOR MAKING THE SAME CYTEC INDUSTRIES INC. (US) 2020-09-17 US disclosed
EP-3240829-B1 BENZOXAZINES AND COMPOSITIONS CONTAINING THE SAME CYTEC IND INC (US) 2019-08-21 EP disclosed
US-20160185908-A1 BENZOXAZINES AND COMPOSITIONS CONTAINING THE SAME CYTEC INDUSTRIES INC. (US) 2016-06-30 US disclosed
US-20160185908-A1 BENZOXAZINES AND COMPOSITIONS CONTAINING THE SAME CYTEC INDUSTRIES INC. (US) 2016-06-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200291179-A1 COMPOSITE MATERIALS CONTAINING BENZOXAZINES AND METHOD FOR MAKING THE SAME F12, COL1A1, BRIX1 VDR 1918/4885MAPT 2756/4885GAA 963/4885
US-11566106-B2 Composite materials containing benzoxazines and method for making the same F12, COL1A1, BRIX1 VDR 1918/4885MAPT 2756/4885GAA 963/4885
US-20230133556-A1 BENZOXAZINES AND COMPOSITIONS CONTAINING THE SAME F12, BRIX1, COL1A1 VDR 1606/4885MAPT 2194/4885GAA 801/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.