SCHEMBL17877

SCHEMBL17877

O=c1[nH]c(-c2ccnc(C(F)(F)F)n2)no1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMO O15229 1/20 0.39
ALDH1A1 P00352 2/20 0.38
IDH1 O75874 5/20 0.37
IDH2 P48735 4/20 0.37
ALOX5 P09917 1/20 0.36
RARB P10826 1/20 0.35
ADH5 P11766 1/20 0.35
MALT1 Q9UDY8 1/20 0.34
BPGM P07738 1/20 0.32
HSP90AA1 P07900 1/20 0.32
HTT P42858 1/20 0.32
KMT2A Q03164 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PARP1 P09874 1/20 0.32
CYP17A1 P05093 1/20 0.31
TAS2R14 Q9NYV8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL600564 0.77 KMO (0.36) KMOALDH1A1ALOX5RARBKMT2A
SCHEMBL2338601 0.77 KMO (0.45) KMOALDH1A1ALOX5RARBADH5
SCHEMBL18554 0.76 ALDH1A1 (0.36) KMOALDH1A1ALOX5RARBADH5
SCHEMBL16393167 0.75 IDH1 (0.38) ALDH1A1IDH1IDH2MALT1HSP90AA1
SCHEMBL18781 0.73 ALDH1A1 (0.38) KMOALDH1A1IDH1IDH2ALOX5
SCHEMBL2335008 0.72 KMO (0.44) KMOALDH1A1ALOX5RARBADH5
SCHEMBL2340435 0.71 ALDH1A1 (0.42) KMOALDH1A1
SCHEMBL603910 0.70 RARB (0.39) KMOALDH1A1RARBKMT2A
SCHEMBL2336517 0.70 KMO (0.42) KMOALDH1A1ALOX5RARBADH5
SCHEMBL1935751 0.70 NOTUM (0.45) KMOALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012025460-A1 OXADIAZOLINONE DERIVATIVES AND USE THEREOF IN PEST CONTROL BAYER CROPSCIENCE AG (DE) 2012-03-01 WO disclosed