SCHEMBL18781

SCHEMBL18781

O=c1[nH]c(-c2nccc(C(F)(F)F)n2)no1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.38
ALOX5 P09917 1/20 0.36
IDH1 O75874 4/20 0.36
ADRB1 P08588 1/20 0.35
RARB P10826 1/20 0.35
IDH2 P48735 2/20 0.35
NR1I2 O75469 1/20 0.35
BRS3 P32247 1/20 0.35
ADH5 P11766 1/20 0.35
HDAC4 P56524 3/20 0.34
KMO O15229 1/20 0.34
PIM1 P11309 1/20 0.34
PIM3 Q86V86 1/20 0.34
PIM2 Q9P1W9 1/20 0.34
TAS2R14 Q9NYV8 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17833 0.82 IDH1 (0.36) IDH1ADRB1IDH2HDAC4PIM1
SCHEMBL18186 0.80 ALDH1A1 (0.39) ALDH1A1ALOX5RARBPIM1PIM2
SCHEMBL15102668 0.75 IDH1 (0.36) IDH1ADRB1IDH2HDAC4PIM1
SCHEMBL29763275 0.75 IDH1 (0.36) IDH1ADRB1IDH2HDAC4PIM1
SCHEMBL18780 0.75 IDH1 (0.36) IDH1ADRB1IDH2HDAC4PIM1
SCHEMBL17877 0.73 KMO (0.39) ALDH1A1ALOX5IDH1RARBIDH2
SCHEMBL601266 0.72 HPGD (0.51) ALDH1A1KMOHPGD
SCHEMBL2338601 0.71 KMO (0.45) ALDH1A1ALOX5ADRB1RARBADH5
SCHEMBL2341679 0.70 ALOX5 (0.38) ALDH1A1ALOX5RARBADH5KMO
SCHEMBL18108 0.69 KMO (0.52) ALDH1A1RARBNR1I2BRS3ADH5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012025460-A1 OXADIAZOLINONE DERIVATIVES AND USE THEREOF IN PEST CONTROL BAYER CROPSCIENCE AG (DE) 2012-03-01 WO disclosed