Sugi Predict

Sugi Predict / Compounds / SCHEMBL1787738

SCHEMBL1787738

SCHEMBL1787738

COC(=O)c1cc(NN)ccc1Cl

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.67
▸ KDM4E B2RXH2 3/20 0.67
▸ POLB P06746 2/20 0.67
▸ NPC1 O15118 1/20 0.67
▸ RAB9A P51151 1/20 0.67
▸ TDP1 Q9NUW8 1/20 0.67
▸ MEN1 O00255 5/20 0.61
▸ KMT2A Q03164 5/20 0.61
▸ LMNA P02545 4/20 0.61
▸ SMN1; SMN2 Q16637 3/20 0.61
▸ HTT P42858 1/20 0.58
▸ NPSR1 Q6W5P4 1/20 0.58
▸ ALDH1A1 P00352 3/20 0.52
▸ GAA P10253 2/20 0.52
▸ L3MBTL1 Q9Y468 1/20 0.52
▸ CASR P41180 1/20 0.49
▸ TSHR P16473 2/20 0.48
▸ ABL1 P00519 1/20 0.47
▸ USP2 O75604 1/20 0.47
▸ CDK1 P06493 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5837444 0.98 MAPT (0.65) MAPTKDM4EPOLBNPC1RAB9A
SCHEMBL4157373 0.86 MAPT (0.53) MAPTKDM4EPOLBNPC1RAB9A
Hydrochloric Acid SCHEMBL17825653 0.85 MAPT (0.51) MAPTKDM4EPOLBNPC1RAB9A
SCHEMBL12611683 0.84 MEN1 (0.63) MAPTKDM4EPOLBNPC1RAB9A
SCHEMBL18094289 0.84 KMT2A (0.62) MAPTKDM4EPOLBNPC1RAB9A
SCHEMBL19966904 0.83 KMT2A (0.67) MAPTKDM4EPOLBNPC1RAB9A
Hydrochloric Acid SCHEMBL6279402 0.83 NPC1 (0.51) MAPTKDM4EPOLBNPC1RAB9A
Hydrochloric Acid SCHEMBL6279400 0.83 NPC1 (0.51) MAPTKDM4EPOLBNPC1RAB9A
Hydrochloric Acid SCHEMBL29205352 0.83 MEN1 (0.61) MAPTKDM4EPOLBNPC1RAB9A
SCHEMBL14499065 0.81 KMT2A (0.73) MAPTKDM4EPOLBMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105873906-B Compound for controlling arthropods 拜耳作物科学股份公司 2019-07-16 — — CN disclosed
CN-106103414-B Substituted benzamides for arthropod processing 拜耳作物科学股份公司 2019-07-16 — — CN disclosed
US-10150737-B2 Compounds for controlling arthropods BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-12-11 — — US disclosed
US-9758485-B2 Compounds for controlling arthropods BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-09-12 — — US disclosed
CN-106103414-A The substituted benzamides processed for arthropod 拜耳作物科学股份公司 2016-11-09 — — CN disclosed
WO-2016174052-A1 ANTIPARASITIC COMBINATIONS BAYER ANIMAL HEALTH GMBH (DE) 2016-11-03 — — WO disclosed
US-20160297765-A1 NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS ELANCO ANIMAL HEALTH GMBH (DE) 2016-10-13 — — US disclosed
US-20160278379-A1 NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS ELANCO ANIMAL HEALTH GMBH (DE) 2016-09-29 — — US disclosed
US-20130203730-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2013-08-08 — — US disclosed
US-20130203730-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2013-08-08 — — US disclosed
EP-2205576-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS AstraZeneca AB (SE) 2010-07-14 — — EP disclosed
US-20090186870-A1 Therapeutic Agents - 802 ASTRAZENECA AB (SE) 2009-07-23 — — US disclosed
US-20090186870-A1 Therapeutic Agents - 802 ASTRAZENECA AB (SE) 2009-07-23 — — US disclosed
US-20090186870-A1 Therapeutic Agents - 802 ASTRAZENECA AB (SE) 2009-07-23 — — US disclosed
WO-2009047558-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2009-04-16 — — WO disclosed
US-20060217430-A1 Benzamide inhibitors of the P2X7 receptor DOMBROSKI MARK A 2006-09-28 — — US disclosed
US-7071223-B1 Benzamide inhibitors of the P2X7 receptor PFIZER, INC. (US) 2006-07-04 — — US disclosed
EP-1581507-A1 BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR Pfizer Products Inc. (US) 2005-10-05 — — EP disclosed
WO-2004058731-A1 BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR PFIZER PRODUCTS INC. (US) 2004-07-15 — — WO disclosed
EP-0138527-A2 Herbicidal pyrazole derivatives NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1985-04-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217430-A1 Benzamide inhibitors of the P2X7 receptor IL1R1, P2RY1, P2RX1 MAPT 4029/4885KDM4E 4185/4885POLB 4165/4885
US-20130203730-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS GPR119, GHSR, GLP1R MAPT 3413/4885KDM4E 1188/4885POLB 4687/4885
US-20090186870-A1 Therapeutic Agents - 802 GPR119, SLC5A2, MC2R MAPT 4300/4885KDM4E 3524/4885POLB 3987/4885
US-20160278379-A1 NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS CYP4X1, CYP4B1, SERPINB6 MAPT 3991/4885KDM4E 2138/4885POLB 3475/4885
US-10150737-B2 Compounds for controlling arthropods SERPINB6, CYP4X1, C1S MAPT 3475/4885KDM4E 2256/4885POLB 3413/4885
US-20160297765-A1 NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS CYP4X1, CYP4B1, SERPINB6 MAPT 3991/4885KDM4E 2138/4885POLB 3475/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.