Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNPH1 | O43598 | 8/20 | 0.72 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.69 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.67 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.67 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.67 |
| ▸ | LDHA | P00338 | 1/20 | 0.67 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.67 |
| ▸ | FBP1 | P09467 | 1/20 | 0.67 |
| ▸ | SRC | P12931 | 1/20 | 0.67 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.67 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.67 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.67 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20705930 | 1.00 | DNPH1 (0.72) | DNPH1TAS1R3TAS1R1ADORA1PRKAB2 | |
| SCHEMBL17881927 | 1.00 | DNPH1 (0.72) | DNPH1TAS1R3TAS1R1ADORA1PRKAB2 | |
| SCHEMBL17868387 | 1.00 | DNPH1 (0.72) | DNPH1TAS1R3TAS1R1ADORA1PRKAB2 | |
| SCHEMBL29692558 | 0.92 | P2RX3 (0.78) | DNPH1TRPM2SRCP2RY2P2RY1 | |
| SCHEMBL29389555 | 0.92 | P2RX3 (0.78) | DNPH1TRPM2SRCP2RY2P2RY1 | |
| SCHEMBL8780669 | 0.91 | DNPH1 (0.77) | DNPH1TAS1R3TAS1R1ADORA1PRKAB2 | |
| SCHEMBL8780682 | 0.91 | DNPH1 (0.77) | DNPH1TAS1R3TAS1R1ADORA1PRKAB2 | |
| SCHEMBL30004415 | 0.88 | DNPH1 (0.75) | DNPH1TAS1R3TAS1R1ADORA1PRKAB2 | |
| SCHEMBL4307198 | 0.88 | DNPH1 (0.75) | DNPH1TAS1R3TAS1R1ADORA1PRKAB2 | |
| SCHEMBL26067680 | 0.88 | DNPH1 (0.75) | DNPH1TAS1R3TAS1R1ADORA1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10196412-B2 | Probe for imaging PARP-1 activity | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-02-05 | — | — | US | disclosed |
| US-20160185805-A1 | PROBE FOR IMAGING PARP-1 ACTIVITY | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10196412-B2 | Probe for imaging PARP-1 activity | PARP1, PARP2, PARP12 | DNPH1 1646/4885TAS1R3 2606/4885TAS1R1 2017/4885 |
| US-20160185805-A1 | PROBE FOR IMAGING PARP-1 ACTIVITY | PARP1, PARP2, PARP12 | DNPH1 1646/4885TAS1R3 2606/4885TAS1R1 2017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.