SCHEMBL4307198

SCHEMBL4307198

CNc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNPH1 O43598 9/20 0.75
TAS1R3 Q7RTX0 2/20 0.75
TAS1R1 Q7RTX1 2/20 0.75
ADORA1 P30542 3/20 0.73
P2RY1 P47900 2/20 0.73
PRKAB2 O43741 1/20 0.73
TRPM2 O94759 1/20 0.73
LDHA P00338 1/20 0.73
ADRB2 P07550 1/20 0.73
FBP1 P09467 1/20 0.73
SRC P12931 1/20 0.73
P2RY2 P41231 1/20 0.73
PRKAG1 P54619 1/20 0.73
PRKAA2 P54646 1/20 0.73
PDE4D Q08499 1/20 0.73
KCNH2 Q12809 1/20 0.73
PRKAA1 Q13131 1/20 0.73
PDE3A Q14432 1/20 0.73
SMN1; SMN2 Q16637 1/20 0.73
P2RY11 Q96G91 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26067680 1.00 DNPH1 (0.75) DNPH1TAS1R3TAS1R1ADORA1P2RY1
SCHEMBL30004415 1.00 DNPH1 (0.75) DNPH1TAS1R3TAS1R1ADORA1P2RY1
SCHEMBL14358309 0.99 DNPH1 (0.74) DNPH1TAS1R3TAS1R1ADORA1P2RY1
SCHEMBL26067558 0.93 DNPH1 (0.66) DNPH1TAS1R3TAS1R1ADORA1P2RY1
SCHEMBL26067580 0.93 DNPH1 (0.66) DNPH1TAS1R3TAS1R1ADORA1P2RY1
SCHEMBL31396265 0.92 P2RX3 (0.77) DNPH1TAS1R3TAS1R1P2RY1TRPM2
SCHEMBL14358316 0.92 ADORA1 (0.77) DNPH1TAS1R3TAS1R1ADORA1P2RY1
SCHEMBL18574268 0.92 P2RY1 (0.66) DNPH1TAS1R3TAS1R1ADORA1P2RY1
SCHEMBL14929511 0.92 P2RY1 (0.66) DNPH1TAS1R3TAS1R1ADORA1P2RY1
SCHEMBL14946362 0.92 P2RY1 (0.66) DNPH1TAS1R3TAS1R1ADORA1P2RY1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11185100-B2 Methods for modulating taste receptors MARS, INCORPORATED (US) 2021-11-30 US claimed
US-20140296167-A1 GLYCOSYLATION SITE-SPECIFIC ANTIBODIES AND ANTI-CANCER COMPOUNDS DETROIT R&D, INC. 2014-10-02 US claimed
US-12214347-B2 Nanopore/nanowell electrode enabled exonuclease sequencing ELECTRONIC BIOSCIENCES, INC. (US) 2025-02-04 US disclosed
US-20240287516-A1 COMPOSITIONS AND METHODS OF USE FOR MUTATED HOTAIR IN THE TREATMENT OF CANCERS UNITED STATES GOVERNMENT 2024-08-29 US disclosed
EP-4403042-A2 FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME Mars, Incorporated (US) 2024-07-24 EP disclosed
EP-3229612-B1 USE OF FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME MARS INC (US) 2024-06-26 EP disclosed
US-20230405580-A1 NANOPORE/NANOWELL ELECTRODE ENABLED EXONUCLEASE SEQUENCING ELECTRONIC BIOSCIENCES INC (US) 2023-12-21 US disclosed
EP-4283285-A2 NANOPORE/NANOWELL ELECTRODE ENABLED EXONUCLEASE SEQUENCING Electronic Biosciences Inc. (US) 2023-11-29 EP disclosed
EP-4026916-B1 NANOPORE/NANOWELL ELECTRODE ENABLED EXONUCLEASE SEQUENCING ELECTRONIC BIOSCIENCES INC (US) 2023-10-18 EP disclosed
US-11752497-B2 Nanopore/nanowell electrode enabled exonuclease sequencing ELECTRONIC BIOSCIENCES, INC. (US) 2023-09-12 US disclosed
US-11685923-B2 Methods of enhancing translation ability of RNA molecules, treatments, and kits CORNELL UNIVERSITY (US) 2023-06-27 US disclosed
US-20160354490-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-08 US disclosed
WO-2016094702-A2 METHODS FOR MODULATING TASTE RECEPTORS MARS, INCORPORATED (US) 2016-06-16 WO disclosed
WO-2016094690-A1 FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME MARS, INCORPORATED (US) 2016-06-16 WO disclosed
US-20150307542-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNATX, INC. 2015-10-29 US disclosed
US-20140296167-A1 GLYCOSYLATION SITE-SPECIFIC ANTIBODIES AND ANTI-CANCER COMPOUNDS DETROIT R&D, INC. 2014-10-02 US disclosed
US-20140107189-A1 MODIFIED POLYNUCLEOTIDES ENCODING APOPTOSIS INDUCING FACTOR 1 MODERNA THERAPEUTICS, INC. (US) 2014-04-17 US disclosed
US-20140010861-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE modeRNA Therapeutics (US) 2014-01-09 US disclosed
US-20130266640-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS MODERNA THERAPEUTICS, INC. 2013-10-10 US disclosed
WO-2009127230-A1 MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION CUREVAC GMBH (DE) 2009-10-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160354490-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 DNPH1 1736/4885TAS1R3 1881/4885TAS1R1 2333/4885
US-20130266640-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS NSUN2, RNMT, NSUN3 DNPH1 1229/4885TAS1R3 4333/4885TAS1R1 4149/4885
US-20150307542-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 DNPH1 1736/4885TAS1R3 1881/4885TAS1R1 2333/4885
US-20140010861-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE POLRMT, POLM, POLN DNPH1 2948/4885TAS1R3 3866/4885TAS1R1 3712/4885
US-20140107189-A1 MODIFIED POLYNUCLEOTIDES ENCODING APOPTOSIS INDUCING FACTOR 1 MSH2, APAF1, MCL1 DNPH1 3739/4885TAS1R3 2745/4885TAS1R1 1754/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.