Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 6/20 | 0.48 |
| ▸ | EIF4E | P06730 | 3/20 | 0.46 |
| ▸ | EIF4EBP1 | Q13541 | 3/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.46 |
| ▸ | MAFG | O15525 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | YWHAZ | P63104 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17880423 | 0.97 | KRAS (0.45) | KRASEIF4EEIF4EBP1MCL1MAFG | |
| SCHEMBL17880418 | 0.75 | MDM2 (0.54) | EIF4EEIF4EBP1ESR1 | |
| SCHEMBL13610980 | 0.71 | ESR1 (0.38) | KRASEIF4EEIF4EBP1MCL1ESR1 | |
| SCHEMBL17884290 | 0.69 | MAFG (0.42) | KRASEIF4EEIF4EBP1MCL1MAFG | |
| SCHEMBL10063472 | 0.69 | ESR1 (0.58) | KRASEIF4EEIF4EBP1MCL1ESR1 | |
| SCHEMBL13227599 | 0.68 | MDM2 (0.49) | EIF4EEIF4EBP1ESR1 | |
| SCHEMBL13575404 | 0.66 | ESR1 (0.42) | KRASEIF4EEIF4EBP1MCL1ESR1 | |
| SCHEMBL17880461 | 0.64 | KEAP1 (0.37) | — | |
| SCHEMBL20414054 | 0.63 | KRAS (0.45) | KRASMCL1MAFGESR1 | |
| SCHEMBL6035213 | 0.63 | TFPI (0.59) | YWHAZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160185821-A1 | Z-SELECTIVE OLEFIN METATHESIS OF PEPTIDES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185821-A1 | Z-SELECTIVE OLEFIN METATHESIS OF PEPTIDES | QPCT, PTMS, MAX | KRAS 887/4885EIF4E 2518/4885EIF4EBP1 1910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.