Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.55 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888296 | 0.82 | KDM4E (0.63) | PRMT5WDR77PKMAPEX1CYP2C19 | |
| SCHEMBL17888397 | 0.79 | ALDH1A1 (0.59) | PRMT5WDR77PKMAPEX1CYP2C19 | |
| SCHEMBL13024504 | 0.75 | CHRNB2 (0.63) | PRMT5WDR77KMT2AKDM4EALDH1A1 | |
| SCHEMBL27603665 | 0.74 | CHRNB2 (0.62) | PRMT5WDR77CYP2C19KMT2AKDM4E | |
| Oxalic Acid SCHEMBL1532842 | 0.74 | ALDH1A1 (0.59) | PRMT5WDR77CYP2C19BLMKMT2A | |
| SCHEMBL31430919 | 0.72 | CHRNB2 (0.59) | PRMT5WDR77CYP2C19KMT2AKDM4E | |
| SCHEMBL1962198 | 0.72 | CHRNB2 (0.59) | PRMT5WDR77CYP2C19KMT2AKDM4E | |
| SCHEMBL18701778 | 0.72 | RIPK1 (0.65) | PRMT5WDR77KMT2AKDM4EALDH1A1 | |
| SCHEMBL21078063 | 0.72 | ALDH1A1 (0.64) | PRMT5WDR77KMT2AKDM4EALDH1A1 | |
| SCHEMBL5300891 | 0.72 | LMNA (0.67) | PRMT5WDR77KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008011453-A2 | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLβ-HSD-1 | AMGEN INC. (US) | 2008-01-24 | — | — | WO | disclosed |