Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 11/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KHK | P50053 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16300044 | 0.84 | SMO (0.55) | SMONR3C1CYP11B2PGRMGLL | |
| SCHEMBL17892204 | 0.82 | SMO (0.50) | SMONR3C1CYP11B2PGRKHK | |
| SCHEMBL4286821 | 0.82 | SMO (0.53) | SMONR3C1CYP11B2PGRMGLL | |
| SCHEMBL17892218 | 0.81 | SMO (0.49) | SMONR3C1CYP11B2PGRKHK | |
| SCHEMBL4274224 | 0.79 | SMO (0.53) | SMONR3C1 | |
| SCHEMBL4760701 | 0.79 | SMO (0.56) | SMONR3C1 | |
| SCHEMBL4283364 | 0.77 | SMO (0.58) | SMONR3C1MGLL | |
| SCHEMBL22199134 | 0.77 | NR3C1 (0.57) | SMONR3C1CYP11B2PGRKHK | |
| SCHEMBL30918005 | 0.76 | CYP11B2 (0.72) | SMONR3C1CYP11B2PGR | |
| SCHEMBL30127430 | 0.76 | NR3C1 (0.54) | SMONR3C1CYP11B2PGRKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |