Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17892122 | 0.89 | ATM (0.55) | SCN5ASCN9AMAOBALDH1A1CYP3A4 | |
| SCHEMBL3310151 | 0.80 | ATM (0.56) | ALDH1A1CYP3A4CYP2D6MAPTMAPK1 | |
| SCHEMBL3313145 | 0.79 | ALDH1A1 (0.57) | ALDH1A1MAPTMAPK1LMNAHPGD | |
| SCHEMBL8913587 | 0.77 | ATM (0.52) | ALDH1A1CYP3A4CYP2D6MAPTMAPK1 | |
| SCHEMBL9308762 | 0.77 | ALDH1A1 (0.53) | ALDH1A1CYP3A4CYP2D6MAPTMAPK1 | |
| SCHEMBL9040316 | 0.76 | SCN5A (0.67) | SCN5ASCN9AMAOBALDH1A1ATM | |
| SCHEMBL2550556 | 0.76 | LMNA (0.68) | ALDH1A1MAPK1CYP2C19LMNAHPGD | |
| SCHEMBL20481318 | 0.75 | CHRM2 (0.53) | ALDH1A1LMNAMEN1KMT2ACHRM2 | |
| SCHEMBL9308521 | 0.75 | MEN1 (0.58) | ALDH1A1CYP3A4CYP2D6MAPTMAPK1 | |
| SCHEMBL2870098 | 0.74 | LMNA (0.71) | ALDH1A1MAPK1CYP2C19LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |