Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | DRD4 | P21917 | 5/20 | 0.43 |
| ▸ | SPR | P35270 | 3/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17895839 | 0.81 | PLK1 (0.47) | SPRUSP2LMNAPKMNPC1 | |
| SCHEMBL17895939 | 0.74 | PARP1 (0.36) | SPRUSP2LMNAPKMMAPT | |
| SCHEMBL17896077 | 0.73 | CYP2C19 (0.44) | MAPTRAB9APARP1KDM4EMEN1 | |
| SCHEMBL17896114 | 0.72 | HSD11B1 (0.36) | SPRUSP2LMNAPKMMAPT | |
| SCHEMBL17895886 | 0.72 | ELANE (0.34) | SPRUSP2LMNANPC1MAPT | |
| SCHEMBL17895747 | 0.71 | USP2 (0.33) | SPRUSP2LMNAPKMNPC1 | |
| SCHEMBL17895874 | 0.71 | LMNA (0.37) | SPRUSP2LMNAPKMNPC1 | |
| Hydrochloric Acid SCHEMBL17895907 | 0.71 | USP2 (0.32) | SPRUSP2LMNANPC1MAPT | |
| SCHEMBL17895823 | 0.71 | LMNA (0.35) | SPRUSP2LMNAPKMNPC1 | |
| SCHEMBL17896107 | 0.70 | USP2 (0.34) | SPRUSP2LMNAPKMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | claimed |
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |