Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896053 | 0.82 | LMNA (0.35) | LMNAKDM4EALDH1A1TSHRMAPT | |
| Hydrochloric Acid SCHEMBL17896000 | 0.81 | LMNA (0.34) | LMNAKDM4EALDH1A1TSHRMAPT | |
| SCHEMBL17895998 | 0.80 | CPB2 (0.30) | CPB2 | |
| Hydrochloric Acid SCHEMBL17895825 | 0.79 | — | — | |
| SCHEMBL17896007 | 0.79 | LMNA (0.37) | LMNAKDM4EALDH1A1TSHRMAPT | |
| Hydrochloric Acid SCHEMBL17896090 | 0.78 | LMNA (0.36) | LMNAKDM4EALDH1A1TSHRMAPT | |
| SCHEMBL17895831 | 0.78 | LMNA (0.36) | LMNAKDM4EALDH1A1TSHRMAPT | |
| Hydrochloric Acid SCHEMBL17895824 | 0.77 | LMNA (0.35) | LMNAKDM4EALDH1A1TSHRMAPT | |
| SCHEMBL17896059 | 0.77 | ALDH1A1 (0.36) | LMNAKDM4EALDH1A1TSHRPKM | |
| Hydrochloric Acid SCHEMBL17895933 | 0.76 | ALDH1A1 (0.35) | LMNAKDM4EALDH1A1TSHRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | claimed |
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |