Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.32 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17895968 | 0.99 | KDM4E (0.33) | KDM4EALDH1A1TSHRPKMSMN1; SMN2 | |
| SCHEMBL17896063 | 0.90 | TSHR (0.35) | KDM4EALDH1A1TSHRPKMSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL17896047 | 0.90 | TSHR (0.34) | KDM4EALDH1A1TSHRPKMSMN1; SMN2 | |
| SCHEMBL17896121 | 0.88 | LMNA (0.34) | KDM4EALDH1A1TSHRPKMSMN1; SMN2 | |
| SCHEMBL17896098 | 0.88 | PKM (0.38) | KDM4EALDH1A1TSHRPKMSMN1; SMN2 | |
| SCHEMBL17895780 | 0.87 | LMNA (0.34) | KDM4EALDH1A1TSHRPKMSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL17896062 | 0.87 | PKM (0.37) | KDM4EALDH1A1TSHRPKMSMN1; SMN2 | |
| SCHEMBL17895925 | 0.85 | LMNA (0.33) | KDM4EALDH1A1TSHRPKMSMN1; SMN2 | |
| SCHEMBL17896071 | 0.85 | ALDH1A1 (0.34) | KDM4EALDH1A1TSHRPKMLMNA | |
| SCHEMBL17896017 | 0.85 | LMNA (0.34) | KDM4EALDH1A1TSHRPKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | claimed |
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |