Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 15/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 13/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | BMI1 | P35226 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175785 | 0.86 | CYP11B1 (0.63) | CYP11B2CYP11B1ADRB1ADRA2ACYP19A1 | |
| SCHEMBL10175581 | 0.82 | CYP11B2 (0.71) | CYP11B2CYP11B1ADRB1ADRA2ACYP19A1 | |
| SCHEMBL10176203 | 0.81 | CYP11B2 (0.69) | CYP11B2CYP11B1ADRB1ADRA2ACYP19A1 | |
| SCHEMBL10175433 | 0.77 | CYP11B1 (0.53) | CYP11B2CYP11B1PDE2A | |
| SCHEMBL10175784 | 0.75 | CYP11B1 (0.52) | CYP11B2CYP11B1PDE2A | |
| SCHEMBL10176164 | 0.75 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL17883797 | 0.74 | CYP11B2 (0.57) | CYP11B2CYP11B1PIK3CDPIK3CAADRB1 | |
| SCHEMBL460358 | 0.72 | RAB9A (0.48) | CYP11B2CYP11B1PDE2A | |
| SCHEMBL17896718 | 0.71 | CYP11B2 (0.56) | CYP11B2CYP11B1ADRB1ADRA2ACYP19A1 | |
| SCHEMBL17896676 | 0.71 | CYP11B1 (0.68) | CYP11B2CYP11B1CYP19A1ADRA2BPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |