Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896611 | 0.91 | CYP11B2 (0.50) | ALOX5APCYP11B2CYP11B1PDE2APDE10A | |
| SCHEMBL10175348 | 0.85 | CYP11B2 (0.48) | CYP11B2CYP11B1PTGER4CA12CA1 | |
| SCHEMBL17896760 | 0.85 | CYP11B1 (0.52) | ALOX5APCYP11B2CYP11B1PDE2APDE10A | |
| SCHEMBL17896643 | 0.84 | CYP11B2 (0.66) | CYP11B2CYP11B1 | |
| SCHEMBL10175342 | 0.83 | CYP11B2 (0.46) | CYP11B2CYP11B1PTGER4PTGS2CA12 | |
| SCHEMBL17896641 | 0.83 | CYP11B2 (0.47) | CYP11B2CYP11B1PTGER4 | |
| SCHEMBL17896664 | 0.81 | ALOX5AP (0.54) | ALOX5APCYP11B2CYP11B1PDE2APDE10A | |
| SCHEMBL10175433 | 0.81 | CYP11B1 (0.53) | ALOX5APCYP11B2CYP11B1PDE2APDE10A | |
| SCHEMBL17896621 | 0.81 | SMN1; SMN2 (0.49) | ALOX5APCYP11B2CYP11B1PDE2APDE10A | |
| SCHEMBL17883795 | 0.80 | CYP11B2 (0.47) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |