Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.82 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.80 |
| ▸ | CA12 | O43570 | 6/20 | 0.68 |
| ▸ | CA9 | Q16790 | 6/20 | 0.68 |
| ▸ | CA1 | P00915 | 4/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | NDUFS8 | O00217 | 2/20 | 0.66 |
| ▸ | COXFA4 | O00483 | 2/20 | 0.66 |
| ▸ | NDUFAB1 | O14561 | 2/20 | 0.66 |
| ▸ | NDUFA1 | O15239 | 2/20 | 0.66 |
| ▸ | NDUFS4 | O43181 | 2/20 | 0.66 |
| ▸ | NDUFB5 | O43674 | 2/20 | 0.66 |
| ▸ | NDUFB3 | O43676 | 2/20 | 0.66 |
| ▸ | NDUFC1 | O43677 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 7-Prenyloxycoumarin SCHEMBL4898255 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1MTNR1AALOX15CA12 | |
| SCHEMBL17898120 | 0.89 | ALOX15 (1.00) | KDM4EALDH1A1MTNR1AALOX15CA12 | |
| SCHEMBL17898118 | 0.89 | ALOX15 (1.00) | KDM4EALDH1A1MTNR1AALOX15CA12 | |
| SCHEMBL17898119 | 0.88 | ALOX15 (1.00) | KDM4EALDH1A1MTNR1AALOX15CA12 | |
| SCHEMBL17898114 | 0.88 | ALOX15 (1.00) | KDM4EALDH1A1MTNR1AALOX15CA12 | |
| SCHEMBL17898115 | 0.88 | ALOX15 (1.00) | KDM4EALDH1A1MTNR1AALOX15CA12 | |
| SCHEMBL17898117 | 0.88 | ALOX15 (1.00) | KDM4EALDH1A1MTNR1AALOX15CA12 | |
| SCHEMBL8516023 | 0.81 | CA12 (1.00) | KDM4EALDH1A1MTNR1AALOX15CA12 | |
| SCHEMBL12283954 | 0.80 | CA9 (0.67) | KDM4EALDH1A1ALOX15CA12CA9 | |
| Auraptene SCHEMBL2535029 | 0.80 | ALOX15 (1.00) | KDM4EALDH1A1MTNR1AALOX15CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210301078-A1 | COMPOSITIONS AND METHODS OF MAKING POLYMERIZING NUCLEIC ACIDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-09-30 | — | — | US | disclosed |
| US-11072681-B2 | Compositions and methods of making polymerizing nucleic acids | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-07-27 | — | — | US | disclosed |
| US-20170327633-A1 | COMPOSITIONS AND METHODS OF MAKING POLYMERIZING NUCLEIC ACIDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-11-16 | — | — | US | disclosed |
| US-9403791-B1 | Coumarin derivatives for cancer therapy | WELLESLEY COLLEGE (US) | 2016-08-02 | — | — | US | disclosed |
| US-9403791-B1 | Coumarin derivatives for cancer therapy | WELLESLEY COLLEGE (US) | 2016-08-02 | — | — | US | disclosed |
| US-9388155-B1 | Coumarin derivatives for cancer therapy | WELLESLEY COLLEGE (US) | 2016-07-12 | — | — | US | disclosed |
| US-9388155-B1 | Coumarin derivatives for cancer therapy | WELLESLEY COLLEGE (US) | 2016-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11072681-B2 | Compositions and methods of making polymerizing nucleic acids | RNGTT, NSUN2, POLN | KDM4E 4223/4885ALDH1A1 4369/4885MTNR1A 4394/4885 |
| US-20170327633-A1 | COMPOSITIONS AND METHODS OF MAKING POLYMERIZING NUCLEIC ACIDS | RNGTT, NSUN2, POLN | KDM4E 4223/4885ALDH1A1 4369/4885MTNR1A 4394/4885 |
| US-20210301078-A1 | COMPOSITIONS AND METHODS OF MAKING POLYMERIZING NUCLEIC ACIDS | RNGTT, NSUN2, POLN | KDM4E 4223/4885ALDH1A1 4369/4885MTNR1A 4394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.