Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.45 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16054859 | 0.88 | ALDH1A1 (0.56) | MAPK1RAB9ATSHRSMN1; SMN2MAPT | |
| SCHEMBL17831407 | 0.84 | KMT2A (0.51) | RAB9ASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL20379429 | 0.78 | MAPT (0.54) | RAB9ASMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL5788823 | 0.77 | RAB9A (0.58) | RAB9ATP53NFKB1NFKB2RELA | |
| SCHEMBL1854705 | 0.76 | MAPK1 (0.59) | TDP1MAPK1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4563194 | 0.76 | MAPK1 (0.51) | MAPK1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2772417 | 0.76 | MAPK1 (0.51) | MAPK1KDM4EALDH1A1L3MBTL1DEGS1 | |
| SCHEMBL6100318 | 0.75 | RAB9A (0.65) | MAPK1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL17368462 | 0.74 | RAB9A (0.53) | TDP1MAPK1RAB9ATP53TSHR | |
| SCHEMBL2806502 | 0.74 | KDM4E (0.59) | TDP1MAPK1SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160194290-A1 | DIHYDROPYRIMIDIN-2-ONE COMPOUNDS AND MEDICAL USE THEREOF | SHIONOGI & CO., LTD. (JP) | 2016-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160194290-A1 | DIHYDROPYRIMIDIN-2-ONE COMPOUNDS AND MEDICAL USE THEREOF | REN, PKD2, ALPI | TDP1 3959/4885MAPK1 364/4885RAB9A 1525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.