Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241297 | 0.80 | RAB9A (0.62) | KDM4EALDH1A1NPC1HPGDRAB9A | |
| SCHEMBL1854705 | 0.80 | MAPK1 (0.59) | MAPK1KDM4EL3MBTL1ALDH1A1LMNA | |
| SCHEMBL2772417 | 0.79 | MAPK1 (0.51) | MAPK1KDM4EL3MBTL1ALDH1A1HCAR3 | |
| SCHEMBL11841419 | 0.79 | PTK2 (0.61) | MAPK1KDM4EL3MBTL1ALDH1A1LMNA | |
| SCHEMBL11840192 | 0.79 | RAB9A (0.52) | MAPK1KDM4ELMNANPC1RAB9A | |
| SCHEMBL19116339 | 0.78 | SMN1; SMN2 (0.51) | MAPK1KDM4EL3MBTL1HCAR3NPC1 | |
| SCHEMBL64145 | 0.78 | MAPK1 (0.47) | MAPK1KDM4EL3MBTL1ALDH1A1HCAR3 | |
| SCHEMBL16054859 | 0.77 | ALDH1A1 (0.56) | MAPK1KDM4EL3MBTL1ALDH1A1HCAR3 | |
| SCHEMBL17906363 | 0.76 | TDP1 (0.50) | MAPK1KDM4EL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL6984008 | 0.76 | HCAR3 (0.68) | MAPK1KDM4EL3MBTL1ALDH1A1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |