Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.48 |
| ▸ | BACE1 | P56817 | 7/20 | 0.48 |
| ▸ | BCHE | P06276 | 6/20 | 0.48 |
| ▸ | RB1 | P06400 | 4/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EBP | Q15125 | 1/20 | 0.40 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13279646 | 0.87 | GRIN2B (0.49) | ACHEBACE1BCHERB1GRIN2B | |
| SCHEMBL17907975 | 0.86 | CCR3 (0.50) | ACHEBACE1BCHEGRIN2B | |
| SCHEMBL17907942 | 0.86 | BCHE (0.49) | ACHEBACE1BCHEGRIN2BMEN1 | |
| SCHEMBL17908001 | 0.85 | MAOA (0.47) | ACHEBACE1BCHEGRIN2BMEN1 | |
| SCHEMBL17907961 | 0.81 | BCHE (0.53) | ACHEBACE1BCHEGRIN2B | |
| SCHEMBL17907977 | 0.79 | CCR3 (0.50) | ACHEBACE1BCHEGRIN2B | |
| SCHEMBL17907991 | 0.79 | BCHE (0.49) | ACHEBACE1BCHEGRIN2BMEN1 | |
| SCHEMBL17907999 | 0.76 | BCHE (0.51) | ACHEBACE1BCHEGRIN2B | |
| SCHEMBL6337839 | 0.69 | GRIN2B (0.71) | ACHEBACE1RB1GRIN2B | |
| SCHEMBL18828833 | 0.65 | LTA4H (0.63) | ACHEBACE1BCHERB1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |