Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 11/20 | 0.49 |
| ▸ | ACHE | P22303 | 10/20 | 0.49 |
| ▸ | BACE1 | P56817 | 10/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907942 | 0.91 | BCHE (0.49) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL13279646 | 0.87 | GRIN2B (0.49) | BCHEACHEBACE1GRIN2BDRD4 | |
| SCHEMBL17907977 | 0.86 | CCR3 (0.50) | BCHEACHEBACE1GRIN2BCCR3 | |
| SCHEMBL17907999 | 0.83 | BCHE (0.51) | BCHEACHEBACE1GRIN2BCCR3 | |
| SCHEMBL17907975 | 0.79 | CCR3 (0.50) | BCHEACHEBACE1GRIN2BCCR3 | |
| SCHEMBL17907992 | 0.79 | ACHE (0.48) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL17907979 | 0.77 | PTGDR2 (0.39) | KMT2A | |
| SCHEMBL17908001 | 0.76 | MAOA (0.47) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL17907974 | 0.75 | NOS3 (0.41) | GRIN2B | |
| SCHEMBL17907961 | 0.74 | BCHE (0.53) | BCHEACHEBACE1GRIN2BCCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |