SCHEMBL17913032

SCHEMBL17913032

NC(=S)N(N)c1ccc(Br)cc1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
SLC22A2 O15244 1/20 0.37
SLC22A1 O15245 1/20 0.37
SLC22A3 O75751 1/20 0.37
PLAU P00749 1/20 0.37
IDO1 P14902 2/20 0.36
CYP2A6 P11509 1/20 0.36
NOS1 P29475 2/20 0.35
ALOX15 P16050 2/20 0.35
MAPK1 P28482 1/20 0.35
CTSL P07711 2/20 0.33
ALOX5 P09917 1/20 0.32
MAPT P10636 1/20 0.32
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
NPC1 O15118 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28952769 0.88 ALDH1A1 (0.50) ALDH1A1MAPK1MAPTMAOASMN1; SMN2
SCHEMBL28344499 0.79 ALDH1A1 (0.43) ALDH1A1PLAUNOS1ALOX15MAPK1
SCHEMBL17161281 0.77 ALOX5 (0.44) ALDH1A1SLC22A2SLC22A1SLC22A3PLAU
SCHEMBL17913029 0.77 ALDH1A1 (0.41) ALDH1A1SLC22A2SLC22A1SLC22A3PLAU
SCHEMBL21777201 0.77 MAPT (0.42) ALDH1A1SLC22A2SLC22A1SLC22A3PLAU
SCHEMBL713037 0.76 ALDH1A1 (0.70) ALDH1A1MAPTNPC1SMN1; SMN2
SCHEMBL15559295 0.73 CES2 (0.41) CYP2A6ALOX5MAPTMAOAMAOB
SCHEMBL11382133 0.72 CA1 (0.44) ALDH1A1MAPK1MAPTMAOANPC1
SCHEMBL14697226 0.72 SLC22A2 (0.42) ALDH1A1SLC22A2SLC22A1SLC22A3MAPK1
SCHEMBL17913050 0.72 NOS3 (0.42) ALDH1A1IDO1NOS1MAPTMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016111658-A1 SYNTHESIS OF THIOSEMICARBAZONE DERIVATIVES COMPRISING SULPHONAMIDE GROUP WITH POTENTIAL ANTICONVULSANT ACTIVITY IYIDOGAN AYSEGUL (TR) 2016-07-14 WO claimed
WO-2025046420-A1 COMPOUND TARGETING EGR-1 AND USE THEREOF FOR TREATMENT OF ATOPIC DERMATITIS 주식회사 아제라메디 2025-03-06 WO disclosed
WO-2016111658-A1 SYNTHESIS OF THIOSEMICARBAZONE DERIVATIVES COMPRISING SULPHONAMIDE GROUP WITH POTENTIAL ANTICONVULSANT ACTIVITY IYIDOGAN AYSEGUL (TR) 2016-07-14 WO disclosed