Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.45 |
| ▸ | HTR3B | O95264 | 2/20 | 0.45 |
| ▸ | HTR3A | P46098 | 2/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HAT1 | O14929 | 4/20 | 0.40 |
| ▸ | EP300 | Q09472 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17913422 | 0.87 | HTR3E (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL27890211 | 0.75 | NR4A2 (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL17913753 | 0.74 | AVPR1A (0.45) | DGAT1MAPTAVPR1AALDH1A1L3MBTL1 | |
| SCHEMBL17913693 | 0.73 | AVPR1A (0.42) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL29722237 | 0.72 | ADAM17 (0.66) | MAPTALDH1A1L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL6335017 | 0.72 | ADAM17 (0.66) | MAPTALDH1A1L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL17915220 | 0.72 | MAPT (0.40) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL22045445 | 0.72 | ACMSD (0.37) | DGAT1L3MBTL1NPC1 | |
| SCHEMBL17913425 | 0.72 | CPT1A (0.47) | MAPTALDH1A1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL21274971 | 0.71 | HAT1 (0.61) | AVPR1AALDH1A1KDM4EHAT1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016112088-A1 | ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-07-14 | — | — | WO | disclosed |