Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 10/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | CCR2 | P41597 | 1/20 | 0.55 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27837634 | 0.86 | KDM4E (0.63) | CHRM2TDP1MEN1KMT2ACYP1A2 | |
| SCHEMBL20545632 | 0.82 | CYP1A2 (0.55) | CHRM2TDP1CYP1A2SLC6A4OPRD1 | |
| SCHEMBL29690180 | 0.82 | CYP1A2 (0.55) | CHRM2TDP1CYP1A2SLC6A4OPRD1 | |
| SCHEMBL18753807 | 0.81 | CYP2D6 (0.67) | CXCR4CHRM2TDP1MEN1CHRM1 | |
| SCHEMBL675122 | 0.80 | CXCR4 (0.60) | CXCR4CHRM2TDP1MEN1CHRM1 | |
| SCHEMBL7608588 | 0.80 | CXCR4 (0.60) | CXCR4CHRM2TDP1MEN1CHRM1 | |
| SCHEMBL9829670 | 0.79 | KDM4E (0.66) | TDP1MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL9620928 | 0.77 | KDM4E (0.64) | CXCR4CHRM2TDP1MEN1CHRM1 | |
| SCHEMBL9397289 | 0.77 | CXCR4 (0.60) | CXCR4CHRM2TDP1MEN1CHRM1 | |
| SCHEMBL9185135 | 0.77 | CYP1A2 (0.59) | CHRM2TDP1CYP1A2SLC6A4OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160206592-A1 | METHOD FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS BY INHIBITION OF CXCR4/CXCL12 SIGNALING | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2016-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160206592-A1 | METHOD FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS BY INHIBITION OF CXCR4/CXCL12 SIGNALING | CXCL12, GRM2, GRM1 | CXCR4 5/4885CHRM2 1329/4885TDP1 3133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.