SCHEMBL17943262

SCHEMBL17943262

C[C@H]1C(O)[C@@H](CO)O[C@H]1n1cc(C(=O)NCc2ccc3ccccc3c2)c(N)nc1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC28A2 O43868 1/20 0.44
▸ ADORA2A P29274 4/20 0.41
▸ ADORA2B P29275 2/20 0.41
▸ ADORA3 P0DMS8 2/20 0.41
▸ ADORA1 P30542 2/20 0.41
▸ METTL3 Q86U44 1/20 0.40
▸ LMNA P02545 3/20 0.39
▸ MTOR P42345 2/20 0.39
▸ THRB P10828 2/20 0.39
▸ NCOA1 Q15788 2/20 0.39
▸ NCOA3 Q9Y6Q9 2/20 0.39
▸ MDM2 Q00987 1/20 0.39
▸ GALR3 O60755 1/20 0.37
▸ NR2F2 P24468 1/20 0.37
▸ KLKB1 P03952 1/20 0.37
▸ NT5E P21589 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ GMNN O75496 1/20 0.37
▸ TP53 P04637 1/20 0.37
▸ NFKB1 P19838 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17943264 0.92 ADORA2A (0.43) SLC28A2ADORA2AADORA2BADORA3ADORA1
SCHEMBL17943280 0.91 ADORA2A (0.44) SLC28A2ADORA2AADORA3ADORA1LMNA
SCHEMBL27093275 0.90 SLC28A2 (0.45) SLC28A2ADORA2AADORA2BADORA3ADORA1
SCHEMBL17943267 0.87 SLC28A2 (0.44) SLC28A2ADORA2AADORA2BADORA1
SCHEMBL17943275 0.84 LGALS9 (0.44) ADORA2AADORA2BADORA3ADORA1LMNA
SCHEMBL28076895 0.82 DNMT1 (0.49) GALR3NR2F2DNMT1
SCHEMBL17943263 0.82 ADORA1 (0.42) ADORA2AADORA2BADORA3ADORA1HPGD
SCHEMBL17943276 0.82 ADORA2A (0.43) SLC28A2ADORA2AADORA2BLMNAMTOR
SCHEMBL17943320 0.81 METTL3 (0.34) SLC28A2METTL3GALR3NR2F2KLKB1
SCHEMBL17943269 0.81 METTL3 (0.34) SLC28A2METTL3GALR3NR2F2KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180201641-A1 Cytidine-5-Carboxamide Modified Nucleotide Compositions and Methods Related Thereto SOMALOGIC OPERATING CO. INC. 2018-07-19 — — US disclosed
US-9938314-B2 Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto SOMALOGIC, INC. (US) 2018-04-10 — — US disclosed
US-20160348112-A1 Compositions and Methods for Detecting Microorganisms SOMALOGIC OPERATING CO. INC. 2016-12-01 — — US disclosed
US-20160215013-A1 Cytidine-5-Carboxamide Modified Nucleotide Compositions and Methods Related Thereto SOMALOGIC OPERATING CO. INC. 2016-07-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180201641-A1 Cytidine-5-Carboxamide Modified Nucleotide Compositions and Methods Related Thereto NT5C3B, CDA, RNGTT SLC28A2 108/4885ADORA2A 61/4885ADORA2B 101/4885
US-20160215013-A1 Cytidine-5-Carboxamide Modified Nucleotide Compositions and Methods Related Thereto NT5C3B, CDA, RNGTT SLC28A2 108/4885ADORA2A 61/4885ADORA2B 101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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