Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 14/20 | 0.69 |
| ▸ | AGTR1 | P30556 | 8/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2365 | 0.93 | LTB4R2 (0.80) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL2364 | 0.93 | LTB4R2 (0.80) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL683480 | 0.90 | LTB4R2 (0.75) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL25964113 | 0.89 | LTB4R2 (0.66) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL1639910 | 0.87 | AGTR1 (0.68) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL19342800 | 0.86 | LTB4R2 (0.63) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL12654453 | 0.86 | AGTR1 (0.67) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL683848 | 0.86 | LTB4R2 (0.69) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL23477438 | 0.86 | LTB4R2 (0.61) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL8295440 | 0.85 | LTB4R2 (0.61) | LTB4R2AGTR1ABCB11GP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180002297-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | MIDCAP FINANCIAL TRUST | 2018-01-04 | — | — | US | disclosed |
| US-9701647-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-20170129862-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | MIDCAP FINANCIAL TRUST | 2017-05-11 | — | — | US | disclosed |
| US-9439888-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-20160213648-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | MIDCAP FINANCIAL TRUST | 2016-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170129862-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | GLS, CYP11B2, GLS2 | LTB4R2 1600/4885AGTR1 877/4885ABCB11 331/4885 |
| US-20160213648-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | GLS, CYP11B2, GLS2 | LTB4R2 1600/4885AGTR1 877/4885ABCB11 331/4885 |
| US-20180002297-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | GLS, CYP11B2, GLS2 | LTB4R2 1600/4885AGTR1 877/4885ABCB11 331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.