Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | HPGD | P15428 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | CNR2 | P34972 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.57 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.57 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923383 | 0.90 | SMN1; SMN2 (0.63) | RAB9ASMN1; SMN2HPGDNPC1ALDH1A1 | |
| SCHEMBL17949724 | 0.89 | RAB9A (0.82) | RAB9ASMN1; SMN2HPGDNPC1ALDH1A1 | |
| SCHEMBL17949738 | 0.81 | KMT2A (0.57) | RAB9ASMN1; SMN2HPGDNPC1ALDH1A1 | |
| SCHEMBL6923380 | 0.79 | SMN1; SMN2 (0.78) | RAB9ASMN1; SMN2HPGDNPC1ALDH1A1 | |
| SCHEMBL19749162 | 0.77 | SMN1; SMN2 (0.61) | RAB9ASMN1; SMN2HPGDNPC1ALDH1A1 | |
| SCHEMBL17949731 | 0.74 | SMN1; SMN2 (0.83) | RAB9ASMN1; SMN2HPGDNPC1ALDH1A1 | |
| SCHEMBL12093546 | 0.73 | NPC1 (0.73) | RAB9ASMN1; SMN2HPGDNPC1ALDH1A1 | |
| SCHEMBL703509 | 0.73 | TAS1R3 (1.00) | RAB9ASMN1; SMN2HPGDNPC1ALDH1A1 | |
| SCHEMBL23524513 | 0.73 | SMN1; SMN2 (0.58) | RAB9ASMN1; SMN2HPGDNPC1ALDH1A1 | |
| SCHEMBL6923152 | 0.72 | NOTUM (0.55) | RAB9ASMN1; SMN2HPGDNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528911-B1 | COMPOSITIONS AND METHODS FOR ENHANCING PROTEASOME ACTIVITY | HARVARD COLLEGE (US) | 2017-10-25 | — | — | EP | disclosed |
| US-20160214989-A1 | Compositions and Methods for Enhancing Proteasome Activity | THE ASSAY DEPOT, INC. | 2016-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214989-A1 | Compositions and Methods for Enhancing Proteasome Activity | PSMG3, PSME3, PSMB11 | RAB9A 2509/4885SMN1; SMN2 307/4885HPGD 4170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.